Phenotypes associated with this allele

• Allele Symbol: Srr^tm1.2Jtc
• Allele Name: targeted mutation 1.2, Joseph T Coyle
• Allele ID: MGI:4438917
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Srr^tm1.2Jtc/Srr^tm1.2Jtc	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:4438921
ht2	Srr^tm1.2Jtc/Srr^+	involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6	MGI:4438924

Genotype
MGI:4438921

hm1

• Allelic Composition: Srr^tm1.2Jtc/Srr^tm1.2Jtc
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal nervous system physiology ( J:158266 )

• cortical D-serine levels are approximately 10% of wild-type levels

abnormal excitatory postsynaptic currents ( J:158266 )

• decay kinetics of NMDAR mediated excitatory postsynaptic currents (EPSCs) are significantly slower

• perfusion of hippocampal containing coronal slices with D-serine (10 M) induced a 93% increase compared to a 41.8% increase in wild-type

reduced long-term potentiation ( J:158266 )

• a pairing paradigm fails to induce LTP at Schaffer collateral-CA1 pyramidal neuron synapse

behavior/neurological

abnormal long-term spatial reference memory ( J:158266 )

♂ • male mice, but not female mice, do not spend significantly more time in the target quadrant of the water maze

increased thigmotaxis ( J:158266 )

♀ • females spend significantly less time in the center zone of the activity monitoring chambers during the first session

increased startle reflex ( J:158266 )

hyperactivity ( J:158266 )

♂ • in males but not females

increased vertical activity ( J:158266 )

♂ • in males but not females

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:158266

Genotype
MGI:4438924

ht2

• Allelic Composition: Srr^tm1.2Jtc/Srr⁺
• Genetic Background: involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6

nervous system

abnormal nervous system physiology ( J:158266 )

• cortical D-serine levelsare approximately 70% of wild-type

increased excitatory postsynaptic current amplitude ( J:158266 )

• perfusion of hippocampal containing coronal slices with D-serine (10 M) induced an 81% increase in the amplitude of pharmacologically isolated NMDAR current compared to a 41.8% increase in wild-type