All Phenotypes Ctsz<tm1Thre> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ctsz^tm1Thre
targeted mutation 1, Thomas Reinheckel
MGI:4436876

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctsz^tm1Thre/Ctsz^tm1Thre	FVB.129P2-Ctsz^tm1Thre	MGI:4436879
hm2	Ctsz^tm1Thre/Ctsz^tm1Thre	involves: 129P2/OlaHsd	MGI:5429433
cx3	Ctsb^tm1Jde/Ctsb^tm1Jde Ctsz^tm1Thre/Ctsz^tm1Thre	FVB.129P2-Ctsz^tm1Thre Ctsb^tm1Jde	MGI:4436880
cx4	Ctsb^tm1Jde/Ctsb^tm1Jde Ctsz^tm1Thre/Ctsz^tm1Thre Tg(MMTV-PyVT)634Mul/0	FVB.129P2-Ctsz^tm1Thre Ctsb^tm1Jde Tg(MMTV-PyVT)634Mul	MGI:4436884
cx5	Ctsz^tm1Thre/Ctsz^tm1Thre Tg(MMTV-PyVT)634Mul/0	FVB.129P2-Ctsz^tm1Thre Tg(MMTV-PyVT)634Mul	MGI:4436882

Allelic Composition	Ctsz^tm1Thre/Ctsz^tm1Thre
Genetic Background	FVB.129P2-Ctsz^tm1Thre

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsz^tm1Thre mutation (0 available); any Ctsz mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:157541 )

• normal body weight, and no impairment of reproductive capacity, breeding behavior, or nursing

Allelic Composition	Ctsz^tm1Thre/Ctsz^tm1Thre
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsz^tm1Thre mutation (0 available); any Ctsz mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:172774 )

N	• normal kidney morphology is obseved • no cellular disorganization or enlargement of nuclei is seen in kidney proximal tubular cells

Allelic Composition	Ctsb^tm1Jde/Ctsb^tm1Jde Ctsz^tm1Thre/Ctsz^tm1Thre
Genetic Background	FVB.129P2-Ctsz^tm1Thre Ctsb^tm1Jde

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsb^tm1Jde mutation (3 available); any Ctsb mutation (40 available)
Ctsz^tm1Thre mutation (0 available); any Ctsz mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:157541 )

• no evidence of impaired quality of maternal care or overall health

• normal body weight

• no differences in circulating levels of estrogen and progesterone at day 42 after birth by ELISA

Allelic Composition	Ctsb^tm1Jde/Ctsb^tm1Jde Ctsz^tm1Thre/Ctsz^tm1Thre Tg(MMTV-PyVT)634Mul/0
Genetic Background	FVB.129P2-Ctsz^tm1Thre Ctsb^tm1Jde Tg(MMTV-PyVT)634Mul

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:157541 )

decreased metastatic potential ( J:157541 )

• 70% fewer lung metastases compared with Tg(MMTV-PyVT)634Mul/0 mice

• 80% smaller average metastasis size

• form significantly less and shorter invasive strands in vitro

abnormal tumor morphology ( J:157541 )

• 28% of the tumors are poorly differentiated, compared with 75% of both Tg(MMTV-PyVT)634Mul/0 and Tg(MMTV-PyVT)634Mul/0; Ctsz^tm1Thre/Ctsz^tm1Thre tumors

• more of the tumors are well differentiated or moderately differentiated

decreased tumor growth/size ( J:157541 )

• with nonpalpable and small tumors even at 14 weeks of age

• tumor weight is reduced to 45% compared with Tg(MMTV-PyVT)634Mul/0 mice

increased tumor latency ( J:157541 )

• develop an average of five palpable tumors 7.5 days later than the Tg(MMTV-PyVT)634Mul/0 mice

cellular

decreased apoptosis ( J:157541 )

• decreased TUNEL-positive cells compared with Ctsb^tm1Jde/Ctsb^tm1Jde;Tg(MMTV-PyVT)634Mul/0 mice

integument

increased mammary gland tumor incidence ( J:157541 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:157541 )

Allelic Composition	Ctsz^tm1Thre/Ctsz^tm1Thre Tg(MMTV-PyVT)634Mul/0
Genetic Background	FVB.129P2-Ctsz^tm1Thre Tg(MMTV-PyVT)634Mul

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsz^tm1Thre mutation (0 available); any Ctsz mutation (9 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased mammary gland tumor incidence ( J:157541 )

decreased metastatic potential ( J:157541 )

• form significantly less and shorter invasive strands in vitro compared with Tg(MMTV-PyVT)634Mul/0 controls

increased tumor growth/size ( J:157541 )

• enlarged tumors at week 10 and 14 compared with Tg(MMTV-PyVT)634Mul/0 mice

• no difference in tumor weight at week 14

increased tumor latency ( J:157541 )

• develop an average of five palpable tumors 4.5 days later than the Tg(MMTV-PyVT)634Mul/0 mice

cellular

decreased apoptosis ( J:157541 )

• decreased TUNEL-positive cells compared with Tg(MMTV-PyVT)634Mul/0 mice and Ctsb^tm1Jde/ Ctsb^tm1Jde;Tg(MMTV-PyVT)634Mul/0 mice

integument

increased mammary gland tumor incidence ( J:157541 )

endocrine/exocrine glands

increased mammary gland tumor incidence ( J:157541 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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