All Phenotypes Smug1<tm1a(EUCOMM)Hmgu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Smug1^{tm1a(EUCOMM)Hmgu}
targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
MGI:4435952

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu}	involves: C57BL/6 * C57BL/6N	MGI:5505260
hm2	Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu}	involves: C57BL/6 * C57BL/6N	MGI:5507884
cx3	Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu} Ung^tm1Tld/Ung^tm1Tld	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N	MGI:5505261
cx4	Msh2^tm1Htr/Msh2^tm1Htr Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu} Ung^tm1Tld/Ung^tm1Tld	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N	MGI:5505262
cx5	Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu} Ung^tm1Tld/Ung^tm1Tld	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N	MGI:5507885
cx6	Msh2^tm1Htr/Msh2^tm1Htr Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu} Ung^tm1Tld/Ung^tm1Tld	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N	MGI:5507886

Allelic Composition	Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu}
Genetic Background	involves: C57BL/6 * C57BL/6N
Cell Lines	HEPD0529_1_C05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smug1^{tm1a(EUCOMM)Hmgu} mutation (0 available); any Smug1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:197809 )

N	• mice exhibit normal life expectancy

cellular

decreased sensitivity to induced cell death ( J:197809 )

• mouse embryonic fibroblasts are resistant to 5-hydroxymethyluridine toxicity compared with wild-type cells

abnormal base-excision repair ( J:197809 )

• mice lack 5-hydroxymethyluracil excision activity compared with wild-type mice

• liver cells exhibit reduced 5-fluorouracil excision activity compared with wild-type cells

homeostasis/metabolism

abnormal base-excision repair ( J:197809 )

• mice lack 5-hydroxymethyluracil excision activity compared with wild-type mice

• liver cells exhibit reduced 5-fluorouracil excision activity compared with wild-type cells

Allelic Composition	Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu}
Genetic Background	involves: C57BL/6 * C57BL/6N
Cell Lines	HEPD0529_1_B07

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smug1^{tm1a(EUCOMM)Hmgu} mutation (0 available); any Smug1 mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:197809 )

N	• mice exhibit normal life expectancy

cellular

decreased sensitivity to induced cell death ( J:197809 )

• mouse embryonic fibroblasts are resistant to 5-hydroxymethyluridine toxicity compared with wild-type cells

abnormal base-excision repair ( J:197809 )

• mice lack 5-hydroxymethyluracil excision activity compared with wild-type mice

• liver cells exhibit reduced 5-fluorouracil excision activity compared with wild-type cells

homeostasis/metabolism

abnormal base-excision repair ( J:197809 )

• mice lack 5-hydroxymethyluracil excision activity compared with wild-type mice

• liver cells exhibit reduced 5-fluorouracil excision activity compared with wild-type cells

Allelic Composition	Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu} Ung^tm1Tld/Ung^tm1Tld
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
Cell Lines	HEPD0529_1_C05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smug1^{tm1a(EUCOMM)Hmgu} mutation (0 available); any Smug1 mutation (14 available)
Ung^tm1Tld mutation (0 available); any Ung mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:197809 )

N	• mice exhibit normal life expectancy

cellular

abnormal base-excision repair ( J:197809 )

• liver cells exhibit non-additive reduced 5-fluorouracil excision activity compared with wild-type cells

abnormal mismatch repair ( J:197809 )

• mice lack uracil excision activity from a double-stranded oligodeoxyribonucleotide substrate containing a U:G mismatch

homeostasis/metabolism

abnormal base-excision repair ( J:197809 )

• liver cells exhibit non-additive reduced 5-fluorouracil excision activity compared with wild-type cells

abnormal mismatch repair ( J:197809 )

• mice lack uracil excision activity from a double-stranded oligodeoxyribonucleotide substrate containing a U:G mismatch

Allelic Composition	Msh2^tm1Htr/Msh2^tm1Htr Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu} Ung^tm1Tld/Ung^tm1Tld
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
Cell Lines	HEPD0529_1_C05

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2^tm1Htr mutation (1 available); any Msh2 mutation (95 available)
Smug1^{tm1a(EUCOMM)Hmgu} mutation (0 available); any Smug1 mutation (14 available)
Ung^tm1Tld mutation (0 available); any Ung mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:197809 )

• mean life expectancy is 107 days compared with 223 days for Msh2^tm1Htr homozygotes

preweaning lethality, incomplete penetrance ( J:197809 )

• fewer than expected mice are identified at weaning

neoplasm

increased tumor incidence ( J:197809 )

• in all mice that die

increased lymphoma incidence ( J:197809 )

• in 4 of 5 mice with tumors

Allelic Composition	Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu} Ung^tm1Tld/Ung^tm1Tld
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
Cell Lines	HEPD0529_1_B07

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:197809 )

N	• mice exhibit normal life expectancy

cellular

abnormal base-excision repair ( J:197809 )

• liver cells exhibit non-additive reduced 5-fluorouracil excision activity compared with wild-type cells

abnormal mismatch repair ( J:197809 )

• mice lack uracil excision activity from a double-stranded oligodeoxyribonucleotide substrate containing a U:G mismatch

homeostasis/metabolism

abnormal base-excision repair ( J:197809 )

• liver cells exhibit non-additive reduced 5-fluorouracil excision activity compared with wild-type cells

abnormal mismatch repair ( J:197809 )

• mice lack uracil excision activity from a double-stranded oligodeoxyribonucleotide substrate containing a U:G mismatch

Allelic Composition	Msh2^tm1Htr/Msh2^tm1Htr Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu} Ung^tm1Tld/Ung^tm1Tld
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
Cell Lines	HEPD0529_1_B07

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:197809 )

• mean life expectancy is 107 days compared with 223 days for Msh2^tm1Htr homozygotes

preweaning lethality, incomplete penetrance ( J:197809 )

• fewer than expected mice are identified at weaning

neoplasm

increased tumor incidence ( J:197809 )

• in all mice that die

increased lymphoma incidence ( J:197809 )

• in 4 of 5 mice with tumors

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