About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Smoc1tm1a(EUCOMM)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4431709
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi MGI:5056093
ht2
Smoc1tm1a(EUCOMM)Wtsi/Smoc1+ C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi/H MGI:5782194


Genotype
MGI:5056093
hm1
Allelic
Composition
Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi
Genetic
Background
C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smoc1tm1a(EUCOMM)Wtsi mutation (2 available); any Smoc1 mutation (33 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Ophthalmo-acromelic-like phenotype in Smoc1tm1a(EUCOMM)Wtsi/Smoc1tm1a(EUCOMM)Wtsi mice

mortality/aging
• all mice die at or soon after birth

vision/eye
• reduced diameter
• the retinal pigmented epithelium extends into the optic nerve unlike in wild-type mice
• in 56% of mice
• in 56% of mice

limbs/digits/tail
• osseous syndactyly

growth/size/body
• in 4 of 12 mice
• in neonates

craniofacial
• in 4 of 12 mice

nervous system
• reduced diameter

digestive/alimentary system
• in 4 of 12 mice

embryo

skeleton

pigmentation
• the retinal pigmented epithelium extends into the optic nerve unlike in wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
microphthalmia with limb anomalies DOID:0060861 OMIM:206920
J:174198




Genotype
MGI:5782194
ht2
Allelic
Composition
Smoc1tm1a(EUCOMM)Wtsi/Smoc1+
Genetic
Background
C57BL/6N-Smoc1tm1a(EUCOMM)Wtsi/H
Cell Lines EPD0348_1_C03
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smoc1tm1a(EUCOMM)Wtsi mutation (2 available); any Smoc1 mutation (33 available)
Data Sources
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body

integument

pigmentation





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/12/2024
MGI 6.23
The Jackson Laboratory