Phenotypes associated with this allele
Allelic
Composition |
Fgfr2tm2Ewj/Fgfr2+
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Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm2Ewj mutation
(0 available);
any
Fgfr2 mutation
(87 available)
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nervous system
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• 1 of 14 mice exhibit severe brain asymmetry unlike in wild-type mice
• 1 of 14 mice exhibit mild brain asymmetry unlike in wild-type mice
• rostrocaudal brain length in many mice is decreased compared to in wild-type mice
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• cerebral height in many mice is increased compared to in wild-type mice
• mice exhibit cerebral asymmetry to varying degrees compared with wild-type mice
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skeleton
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• at P0, mice exhibit variation in the pattern and degree of coronal suture closure compared with wild-type mice
• mice exhibit unilateral or bilateral coronal suture synostosis unlike wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgfr2tm2Ewj mutation
(0 available);
any
Fgfr2 mutation
(87 available)
Tg(EIIa-cre)C5379Lmgd mutation
(4 available)
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Skeletal abnormalities in Fgfr2tm2Ewj/Fgfr2+ Tg(EIIa-cre)C5379Lmgd/0 mice
mortality/aging
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• almost half of all mice die within 24 to 36 hours of birth
• most mice die within 2 weeks of birth with very few surviving to 3 weeks
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skeleton
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• mice exhibit a patent inter-premaxillary suture with fusion of the premaxilla-maxillary sutures unlike wild-type mice
• mice exhibit premature closure of the suture between the zygomatic process of the maxilla and the zygomatic bones and the premaxillary-maxillary sutures unlike wild-type mice
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• with proximate osteogenic fronts and cellular disorganization at P0
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• at E16.5 to P0, mice exhibit ectopic cartilage at the sagittal suture unlike wild-type mice
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• the anterior and overall length of the cranial base is decreased compared to in wild-type mice
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• skull height is increased compared to in wild-type mice
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• the zygomatic process of the maxilla and malar bone are fused unlike in wild-type mice
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• the nasal region is shorter than in wild-type mice and cre-recombined Fgfr2tm1Ewj heterozygotes
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• the zygomatic process of the maxilla and malar bone are fused unlike in wild-type mice
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• at P0, all mice exhibit bony fusions of the sternum unlike wild-type mice
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• coronal sutures exhibit increased osteogenic differentiation and accelerated bone growth compared to in wild-type mice
• however, apoptosis rates at coronal sutures is normal
• at E17.5 to P0, the physis hypertrophic zone is disorganized compared to in wild-type mice
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• as determined by marker expression at E19, osteoblast differentiation at the chondro-osseuous junction and the metaphysis is increased compared to in wild-type mice
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• at E19, osteoblast proliferation at the chondro-osseuous junction and the metaphysis is increased compared to in wild-type mice
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• mice exhibit unilateral or bilateral coronal synostosis unlike wild-type mice
• at P0, mice exhibit coronal suture presynostosis unlike wild-type mice
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craniofacial
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• mice exhibit a patent inter-premaxillary suture with fusion of the premaxilla-maxillary sutures unlike wild-type mice
• mice exhibit premature closure of the suture between the zygomatic process of the maxilla and the zygomatic bones and the premaxillary-maxillary sutures unlike wild-type mice
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• with proximate osteogenic fronts and cellular disorganization at P0
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• at E16.5 to P0, mice exhibit ectopic cartilage at the sagittal suture unlike wild-type mice
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• the anterior and overall length of the cranial base is decreased compared to in wild-type mice
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• skull height is increased compared to in wild-type mice
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• the zygomatic process of the maxilla and malar bone are fused unlike in wild-type mice
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• the nasal region is shorter than in wild-type mice and cre-recombined Fgfr2tm1Ewj heterozygotes
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• the zygomatic process of the maxilla and malar bone are fused unlike in wild-type mice
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• from E15.5 to P0, all mice exhibit bilaterally incomplete fusion at the junction of the primary and secondary palatal shelves unlike in wild-type mice
• the midline suture between the horizontal plates of the palatine bones is patent unlike in wild-type mice
• in 9 of 10 mice the suture between the horizontal plate of the palatine bone and the palatal shelf of the maxilla is patent compared with 3 of 7 wild-type mice
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growth/size/body
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• the nasal region is shorter than in wild-type mice and cre-recombined Fgfr2tm1Ewj heterozygotes
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• from E15.5 to P0, all mice exhibit bilaterally incomplete fusion at the junction of the primary and secondary palatal shelves unlike in wild-type mice
• the midline suture between the horizontal plates of the palatine bones is patent unlike in wild-type mice
• in 9 of 10 mice the suture between the horizontal plate of the palatine bone and the palatal shelf of the maxilla is patent compared with 3 of 7 wild-type mice
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digestive/alimentary system
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• from E15.5 to P0, all mice exhibit bilaterally incomplete fusion at the junction of the primary and secondary palatal shelves unlike in wild-type mice
• the midline suture between the horizontal plates of the palatine bones is patent unlike in wild-type mice
• in 9 of 10 mice the suture between the horizontal plate of the palatine bone and the palatal shelf of the maxilla is patent compared with 3 of 7 wild-type mice
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limbs/digits/tail
cellular
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• as determined by marker expression at E19, osteoblast differentiation at the chondro-osseuous junction and the metaphysis is increased compared to in wild-type mice
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• at E19, osteoblast proliferation at the chondro-osseuous junction and the metaphysis is increased compared to in wild-type mice
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vision/eye
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• intercanthal distance is reduced compared to in wild-type mice
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respiratory system
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• the nasal region is shorter than in wild-type mice and cre-recombined Fgfr2tm1Ewj heterozygotes
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Analysis Tools