Mouse Genome Informatics
cx1
    Gt(ROSA)26Sortm1(Thy1-FBXL2)Wata/Gt(ROSA)26Sor+
Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0

involves: C57BL/6 * C57BL/6N * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• mice exhibit a reduction in amyloid plaques compared with Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte mice

other phenotype
• mice exhibit a reduction in amyloid plaques compared with Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte mice


Mouse Genome Informatics
tg2
    Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte
involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• mice exhibit 85% survival
• 2 of 13 mice die before 12 months of age

nervous system
• dense-core plaques are encompassed by a sphere of early-dystrophic, swollen neurites with ubiquitin accumulation unlike in wild-type mice
• as early as 3 to 5 months, mice exhibit plaques in the anterior neocortex and subiculum unlike wild-type mice
• mmice exhibit plaque accumulation in the posterior neocortex, CA1 through 4 regions of the hippocampus, amygdala and related limbic structures, and thalamus unlike in wild-type mice
• plaques also accumulate in the olfactory bulb, colliculi, brainstem, and the striatum
• at 8 months, large plaques develop in the thalamus compared with wild-type mice
• older mice develop diffuse deposits of beta-amyloid
• plaque size increases with age

behavior/neurological
• at 4 months but not in older mice, anxiety related behaviors are increased with mice spending less time in the center of an open field and entering the open sector of a zero maze compared with wild-type mice
• at 12 months, mice exhibit a deficit in episodic memory with reduced exploration of a novel object compared with wild-type mice
• at 12 months, mice exhibit a deficit in episodic memory with reduced exploration of a novel object compared with wild-type mice
• at 12 months, mice exhibit reduced performance in a Morris water maze test compared with wild-type mice
• at 12 months, mice from the cross-sectional cohort display poor memory in a Morris water maze compared with wild-type mice
• at 4 months but not in older mice, exploratory activity is decreased in a Y maze compared with wild-type mice

immune system

other phenotype
• as early as 3 to 5 months, mice exhibit plaques in the anterior neocortex and subiculum unlike wild-type mice
• mmice exhibit plaque accumulation in the posterior neocortex, CA1 through 4 regions of the hippocampus, amygdala and related limbic structures, and thalamus unlike in wild-type mice
• plaques also accumulate in the olfactory bulb, colliculi, brainstem, and the striatum
• at 8 months, large plaques develop in the thalamus compared with wild-type mice
• older mice develop diffuse deposits of beta-amyloid
• plaque size increases with age

hematopoietic system

Mouse Models of Human Disease
OMIM IDRef(s)
Alzheimer Disease; AD 104300 J:155410


Mouse Genome Informatics
tg3
    Tg(Thy1-PSEN1*M146V,-APP*Swe)10Arte/0
involves: C57BL/6 * CBA
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
nervous system
• as early as 3 to 5 months, mice exhibit plaques in the anterior neocortex and subiculum unlike wild-type mice
• mice exhibit plaque accumulation in the posterior neocortex, CA1 through 4 regions of the hippocampus, amygdala, and related limbic structures unlike in wild-type mice
• at 10 to 11 months, large plaques develop in the thalamus unlike in wild-type mice

other phenotype
• as early as 3 to 5 months, mice exhibit plaques in the anterior neocortex and subiculum unlike wild-type mice
• mice exhibit plaque accumulation in the posterior neocortex, CA1 through 4 regions of the hippocampus, amygdala, and related limbic structures unlike in wild-type mice
• at 10 to 11 months, large plaques develop in the thalamus unlike in wild-type mice