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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
transgene insertion 1, Robert L Nussbaum
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
involves: 129S6/SvEvTac * FVB/N MGI:4421411

involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sncatm1Nbm mutation (5 available); any Snca mutation (17 available)
Tg(SNCA*A53T)1Nbm mutation (3 available)
Tg(SNCA*A53T)2Nbm mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
• body weigh does not differ from controls measured out to 18 months of age

• males and females exhibit consistently reduced latency to fall beginning at 6 months; this persisted at 1 year of age and more pronounced at 18 months; endurance and coordination in the rotating rod test are abnormal
• total distance traveled in the open field apparatus is reduced compared to controls at 6 months and remains abnormal at 18 months
• distance traveled decreases with age, showing reduced ambulatory distance traveled compared to controls at 12 and 18 months; reduction is generalized, not specific to a particular type of movement or region

nervous system
• dorsal motor nucleus of the vagus shows no abnormal alpha-synuclein aggregation and any widespread aggregates are not detected in brain homogenates of 5 and 18 month-old animals
• striatal tissue dopamine and dopamine metabolite content are not different from controls at 11 and 18 months
• no progressive loss of dopaminergic neurons in the substantia nigra, pars compacta (SNpc) is observed
• olfaction and cardiac innervation by the autonomic nervous system are not affected by the transgenes
• some dystrophic synapses are observed in rare instances at 12 or 22 months
• protein is present in tyrosine hydroxylase (TH)-immunoreactive neuronal cell bodies within myenteric and submucosal plexuses; varicose TH-positive terminals of noradrenergic sympathetic neurons
• most alpha-synuclein positive neurons, especially in the myenteric plexus are not coincident with TH immunostaining
• proteinase K-resistant alpha-synuclein aggregates are observed in the nuclear and perinuclear cytoplasm of enteric nervous system neurons in mice showing gastrointestinal motility dysfunction

digestive/alimentary system
• proteinase K-resistant alpha-synuclein aggregates are observed in the nuclear and perinuclear cytoplasm of enteric nervous system neurons in mice showing gastrointestinal motility dysfunction
• whole-gut transit time (WGTT) is prolonged compared to controls starting at 3 months and is markedly prolonged at 6 months persisting through 18 months of age; this phenotype does not differ between males and females in contrast to bead expulsion time (distal colonic motility)
• motility of distal colon is reduced compared to controls with males showing around a 4-5 fold prolongation in expulsion compared to controls; reduction is exaggerated compared to females
• this phenotype is present at 3 months and persists through 18 months of age
• amount of stool passed/unit time and stool water content are unchanged at 3 months of age but by 6 months these parameters are reduced to comparable degrees

cardiovascular system
• no defects in autonomic cardiac innervation are detected

• mice show no impairments in olfaction at 12 and 18 months of age
• olfactory bulbs show no degeneration or protein aggregation at 12 and 18 months of age

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
autosomal dominant Parkinson disease 1 DOID:0060367 OMIM:168601

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 6.08
The Jackson Laboratory