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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(SNCA*A30P)2Nbm
transgene insertion 2, Robert L Nussbaum
MGI:4412059
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Sncatm1Nbm/Sncatm1Nbm
Tg(SNCA*A30P)1Nbm/Tg(SNCA*A30P)1Nbm
Tg(SNCA*A30P)2Nbm/Tg(SNCA*A30P)2Nbm
involves: 129S6/SvEvTac * FVB/N MGI:4421410


Genotype
MGI:4421410
cx1
Allelic
Composition
Sncatm1Nbm/Sncatm1Nbm
Tg(SNCA*A30P)1Nbm/Tg(SNCA*A30P)1Nbm
Tg(SNCA*A30P)2Nbm/Tg(SNCA*A30P)2Nbm
Genetic
Background
involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sncatm1Nbm mutation (5 available); any Snca mutation (16 available)
Tg(SNCA*A30P)1Nbm mutation (1 available)
Tg(SNCA*A30P)2Nbm mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
digestive/alimentary system
• whole-gut transit time (WGTT) is significantly prolonged compared to controls starting at 3 months through 12 months of age;
• motility of distal colon is reduced in males compared to controls at 6 and 12 months
• amount of stool passed/unit time and stool water content are unchanged at 3 months of age but by 6 months these parameters are reduced to comparable degrees
• at 12 months of age, changes in stool production and water content are even more marked
• reduction in stool wet weigh results from a reduction in water content and reduction in the dry mass of stool output

behavior/neurological
N
• mice show no motor abnormalities; rotarod latencies and distances traveled in open field tests are similar to controls at 6 and 12 months

Mouse Models of Human Disease
OMIM ID Ref(s)
Parkinson Disease 1, Autosomal Dominant; PARK1 168601 J:156741





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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory