Analysis Tools
digestive/alimentary system
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• whole-gut transit time (WGTT) is significantly prolonged compared to controls starting at 3 months through 12 months of age;
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• motility of distal colon is reduced in males compared to controls at 6 and 12 months
• amount of stool passed/unit time and stool water content are unchanged at 3 months of age but by 6 months these parameters are reduced to comparable degrees
• at 12 months of age, changes in stool production and water content are even more marked
• reduction in stool wet weigh results from a reduction in water content and reduction in the dry mass of stool output
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behavior/neurological
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N |
• mice show no motor abnormalities; rotarod latencies and distances traveled in open field tests are similar to controls at 6 and 12 months
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Parkinson's disease 1 | DOID:0060367 |
OMIM:168601 |
J:156741 | |
