mortality/aging

premature death ( J:154248 )

• most mice die by 1 month of age

nervous system

decreased motor neuron number ( J:154248 )

• in the brain stem and spinal cord at P21

skeleton

abnormal spine curvature ( J:154248 )

• in mice that survive beyond 1 month

behavior/neurological

paraparesis ( J:154248 )

• mice that survive beyond 1 month exhibit hind limb weakness

abnormal gait ( J:154248 )

• in mice that survive beyond 1 month

growth/size

decreased body size ( J:154248 )

• at 3 weeks of age

Mouse Models of Human Disease		OMIM ID	Ref(s)
Spinal Muscular Atrophy, Type I; SMA1		253300	J:154248

cx2

Pfn2^tm1Wit/Pfn2^tm1Wit
Smn1^tm1Msd/Smn1^tm1Rako
involves: 129P2/OlaHsd * C57BL/6 * CD-1

Key:
♀	phenotype observed in females	WTSI	Wellcome Trust Sanger Institute
♂	phenotype observed in males	EuPh	Europhenome
N	normal phenotype

mortality/aging

premature death ( J:154248 )

• most mice die by 1 month of age

growth/size

decreased body size ( J:154248 )

• at 3 weeks of age

cx3

Pfn2^tm1Wit/Pfn2⁺
Smn1^tm1Msd/Smn1^tm1Rako
involves: 129P2/OlaHsd * C57BL/6 * CD-1

Key:
♀	phenotype observed in females	WTSI	Wellcome Trust Sanger Institute
♂	phenotype observed in males	EuPh	Europhenome
N	normal phenotype

mortality/aging

premature death ( J:154248 )

• most mice die by 1 month of age

nervous system

decreased motor neuron number ( J:154248 )

• in the brain stem and spinal cord at 3 weeks of age

growth/size

decreased body size ( J:154248 )

• at 3 weeks of age

weight loss ( J:154248 )