Mouse Genome Informatics
ht1
    Smn1tm1Msd/Smn1tm1Rako
involves: 129P2/OlaHsd * C57BL/6 * CD-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• most mice die by 1 month of age

nervous system
• in the brain stem and spinal cord at P21

skeleton
• in mice that survive beyond 1 month

behavior/neurological
• mice that survive beyond 1 month exhibit hind limb weakness
• in mice that survive beyond 1 month

growth/size/body
• at 3 weeks of age

Mouse Models of Human Disease
OMIM IDRef(s)
Spinal Muscular Atrophy, Type I; SMA1 253300 J:154248


Mouse Genome Informatics
cx2
    Pfn2tm1Wit/Pfn2tm1Wit
Smn1tm1Msd/Smn1tm1Rako

involves: 129P2/OlaHsd * C57BL/6 * CD-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• most mice die by 1 month of age

growth/size/body
• at 3 weeks of age


Mouse Genome Informatics
cx3
    Pfn2tm1Wit/Pfn2+
Smn1tm1Msd/Smn1tm1Rako

involves: 129P2/OlaHsd * C57BL/6 * CD-1
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
mortality/aging
• most mice die by 1 month of age

nervous system
• in the brain stem and spinal cord at 3 weeks of age

growth/size/body
• at 3 weeks of age