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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Smn1tm1Rako
targeted mutation 1, Rashmi Kothary
MGI:4398734
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
Smn1tm1Msd/Smn1tm1Rako involves: 129P2/OlaHsd * C57BL/6 * CD-1 MGI:4398737
cx2
Pfn2tm1Wit/Pfn2tm1Wit
Smn1tm1Msd/Smn1tm1Rako
involves: 129P2/OlaHsd * C57BL/6 * CD-1 MGI:4398738
cx3
Pfn2tm1Wit/Pfn2+
Smn1tm1Msd/Smn1tm1Rako
involves: 129P2/OlaHsd * C57BL/6 * CD-1 MGI:4398739


Genotype
MGI:4398737
ht1
Allelic
Composition
Smn1tm1Msd/Smn1tm1Rako
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smn1tm1Msd mutation (32 available); any Smn1 mutation (60 available)
Smn1tm1Rako mutation (0 available); any Smn1 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die by 1 month of age

nervous system
• in the brain stem and spinal cord at P21

skeleton
• in mice that survive beyond 1 month

behavior/neurological
• mice that survive beyond 1 month exhibit hind limb weakness
• in mice that survive beyond 1 month

growth/size/body
• at 3 weeks of age

Mouse Models of Human Disease
OMIM ID Ref(s)
Spinal Muscular Atrophy, Type I; SMA1 253300 J:154248




Genotype
MGI:4398738
cx2
Allelic
Composition
Pfn2tm1Wit/Pfn2tm1Wit
Smn1tm1Msd/Smn1tm1Rako
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn2tm1Wit mutation (0 available); any Pfn2 mutation (2 available)
Smn1tm1Msd mutation (32 available); any Smn1 mutation (60 available)
Smn1tm1Rako mutation (0 available); any Smn1 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die by 1 month of age

growth/size/body
• at 3 weeks of age




Genotype
MGI:4398739
cx3
Allelic
Composition
Pfn2tm1Wit/Pfn2+
Smn1tm1Msd/Smn1tm1Rako
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pfn2tm1Wit mutation (0 available); any Pfn2 mutation (2 available)
Smn1tm1Msd mutation (32 available); any Smn1 mutation (60 available)
Smn1tm1Rako mutation (0 available); any Smn1 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• most mice die by 1 month of age

nervous system
• in the brain stem and spinal cord at 3 weeks of age

growth/size/body
• at 3 weeks of age





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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory