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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Nmnat2Gt(EUCE0262a08)Hmgu
gene trap EUCE0262a08, Helmholtz Zentrum Muenchen GmbH
MGI:4371844
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Nmnat2Gt(EUCE0262a08)Hmgu/Nmnat2Gt(EUCE0262a08)Hmgu involves: 129P2/OlaHsd * C57BL/6J MGI:5473284
ht2
Nmnat2Gt(EUCE0262a08)Hmgu/Nmnat2Gt(RRF238)Byg involves: 129P2/OlaHsd * C57BL/6J MGI:5543593
cx3
Nmnat2Gt(EUCE0262a08)Hmgu/Nmnat2Gt(EUCE0262a08)Hmgu
Wlds/+
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6Ola MGI:5543591
cx4
Nmnat2Gt(EUCE0262a08)Hmgu/Nmnat2Gt(EUCE0262a08)Hmgu
Wlds/Wlds
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6Ola MGI:5543592


Genotype
MGI:5473284
hm1
Allelic
Composition
Nmnat2Gt(EUCE0262a08)Hmgu/Nmnat2Gt(EUCE0262a08)Hmgu
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nmnat2Gt(EUCE0262a08)Hmgu mutation (0 available); any Nmnat2 mutation (281 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Hunched posture, failure to initiate respiration, and swollen bladders in E18.5 Nmnat2Gt(EUCE0262a08)Hmgu/Nmnat2Gt(RRF238)Byg pups

mortality/aging
• mice die at birth (J:192196)
• fail to initiate breathing and die at birth (J:200901)

respiratory system

behavior/neurological
• at E18.5 (J:192196)
• at birth (J:200901)
• do not move in utero or at birth
• at E18.5

muscle
• appears underdeveloped
• decreased muscle mass
• at E18.5 and P0

renal/urinary system
• at E18.5 and P0 (J:192196)
• at E18.5 (J:200901)

nervous system
• nerve branches in the hindlimb extend only a short distance into the thigh region at E13/13.5 and E14.5 and intercostal nerves appear to lack significant lateral branching at E14.5
• distal branches of the phrenic nerves are absent from the diaphragm at E14.5
• in dorsal root ganglia explant cultures neurite extension stalls at just 2mm by 3 days in vitro and then begins to retract slightly
• in superior cervical ganglia explant cultures neurite extension is stunted
• stunted retinal ganglion cell axons are seen at E18.5
• in explants cortical neurite extension is severely restricted and neurites show significant blebbing by 7 days in vitro
• absence of the olfactory nerve fiber layer
• distal branches of the phrenic nerves are absent from the diaphragm at E14.5
• axons are absent from distal regions of the hindlimb
• stunted retinal ganglion cell axons are seen at E18.5
• however, no significant loss of retinal ganglion cells is detected
• absence of healthy looking gracile tract axons in the dorsal column of the spinal cord
• axons fall short of the optic chiasma and the optic tract is essentially absent
• decrease or absence of corticospinal tract axons in the dorsal column of cervical segments of the spinal cord at E18.5
• cortical neurites show significant blebbing by 7 days in vitro
• extensive cell death is evident at E18.5 and P0

cellular
• nerve branches in the hindlimb extend only a short distance into the thigh region at E13/13.5 and E14.5 and intercostal nerves appear to lack significant lateral branching at E14.5
• distal branches of the phrenic nerves are absent from the diaphragm at E14.5
• in dorsal root ganglia explant cultures neurite extension stalls at just 2mm by 3 days in vitro and then begins to retract slightly
• in superior cervical ganglia explant cultures neurite extension is stunted
• stunted retinal ganglion cell axons are seen at E18.5
• in explants cortical neurite extension is severely restricted and neurites show significant blebbing by 7 days in vitro

vision/eye
• stunted retinal ganglion cell axons are seen at E18.5
• however, no significant loss of retinal ganglion cells is detected




Genotype
MGI:5543593
ht2
Allelic
Composition
Nmnat2Gt(EUCE0262a08)Hmgu/Nmnat2Gt(RRF238)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nmnat2Gt(EUCE0262a08)Hmgu mutation (0 available); any Nmnat2 mutation (281 available)
Nmnat2Gt(RRF238)Byg mutation (0 available); any Nmnat2 mutation (281 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• survive to at least 12 months of age without any overt abnormalities




Genotype
MGI:5543591
cx3
Allelic
Composition
Nmnat2Gt(EUCE0262a08)Hmgu/Nmnat2Gt(EUCE0262a08)Hmgu
Wlds/+
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6Ola
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nmnat2Gt(EUCE0262a08)Hmgu mutation (0 available); any Nmnat2 mutation (281 available)
Wlds mutation (1 available); any Wld mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• die within a few hours of birth
• unlike Nmnat2 single mutants, double mutants initiate breathing in most cases

behavior/neurological
N
• unlike Nmnat2 single mutants, double mutants do not display a hunched posture

muscle
N
• unlike Nmnat2 single mutants, muscle mass and diaphragm morphology are similar to controls in double mutants

nervous system
N
• at E14.5 intercostal and hindlimb nerves show a grossly normal morphology and loss of dorsal root ganglia cells and spinal cord motor neurons later in development is largely prevented, unlike in Nmnat2 single mutants
• the optic nerve and olfactory bulb defects in single Nmnat2 single mutants are largely rescued in double mutants

renal/urinary system
N
• unlike Nmnat2 single mutants, double mutants do not display a distended bladder




Genotype
MGI:5543592
cx4
Allelic
Composition
Nmnat2Gt(EUCE0262a08)Hmgu/Nmnat2Gt(EUCE0262a08)Hmgu
Wlds/Wlds
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6J * C57BL/6Ola
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nmnat2Gt(EUCE0262a08)Hmgu mutation (0 available); any Nmnat2 mutation (281 available)
Wlds mutation (1 available); any Wld mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
normal phenotype
• double homozygous mice survive to breeding age without overt signs of abnormality and are fertile





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last database update
11/30/2021
MGI 6.17
The Jackson Laboratory