Analysis Tools
mortality/aging
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• mice die at birth
(J:192196)
• fail to initiate breathing and die at birth
(J:200901)
|
respiratory system
atelectasis
(
J:192196
)
behavior/neurological
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• at E18.5
(J:192196)
• at birth
(J:200901)
|
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• do not move in utero or at birth
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muscle
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• appears underdeveloped
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• decreased muscle mass
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• at E18.5 and P0
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renal/urinary system
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• at E18.5 and P0
(J:192196)
• at E18.5
(J:200901)
|
nervous system
|
• nerve branches in the hindlimb extend only a short distance into the thigh region at E13/13.5 and E14.5 and intercostal nerves appear to lack significant lateral branching at E14.5
• distal branches of the phrenic nerves are absent from the diaphragm at E14.5
• in dorsal root ganglia explant cultures neurite extension stalls at just 2mm by 3 days in vitro and then begins to retract slightly
• in superior cervical ganglia explant cultures neurite extension is stunted
• stunted retinal ganglion cell axons are seen at E18.5
• in explants cortical neurite extension is severely restricted and neurites show significant blebbing by 7 days in vitro
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• absence of the olfactory nerve fiber layer
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• distal branches of the phrenic nerves are absent from the diaphragm at E14.5
• axons are absent from distal regions of the hindlimb
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• stunted retinal ganglion cell axons are seen at E18.5
• however, no significant loss of retinal ganglion cells is detected
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• absence of healthy looking gracile tract axons in the dorsal column of the spinal cord
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• axons fall short of the optic chiasma and the optic tract is essentially absent
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• decrease or absence of corticospinal tract axons in the dorsal column of cervical segments of the spinal cord at E18.5
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• cortical neurites show significant blebbing by 7 days in vitro
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• extensive cell death is evident at E18.5 and P0
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cellular
|
• nerve branches in the hindlimb extend only a short distance into the thigh region at E13/13.5 and E14.5 and intercostal nerves appear to lack significant lateral branching at E14.5
• distal branches of the phrenic nerves are absent from the diaphragm at E14.5
• in dorsal root ganglia explant cultures neurite extension stalls at just 2mm by 3 days in vitro and then begins to retract slightly
• in superior cervical ganglia explant cultures neurite extension is stunted
• stunted retinal ganglion cell axons are seen at E18.5
• in explants cortical neurite extension is severely restricted and neurites show significant blebbing by 7 days in vitro
|
vision/eye
|
• stunted retinal ganglion cell axons are seen at E18.5
• however, no significant loss of retinal ganglion cells is detected
|
