Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm3.1Boui mutation
(0 available);
any
Bcl2l11 mutation
(32 available)
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hematopoietic system
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• smaller increase in spleen weight (<1.5 fold)
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• smaller increase in white blood cells numbers (<1.5 fold)
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immune system
N |
• normal in vitro survival assays with several cytotoxic stimuli on sorted thymocyte and B cell populations
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• smaller increase in spleen weight (<1.5 fold)
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• smaller increase in white blood cells numbers (<1.5 fold)
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growth/size/body
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• smaller increase in spleen weight (<1.5 fold)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm3.1Boui mutation
(0 available);
any
Bcl2l11 mutation
(32 available)
Bcl2tm1Dlo mutation
(0 available);
any
Bcl2 mutation
(41 available)
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The Bcl2l11tm3.1Boui mutation ameliorates the degenerative disorders of Bcl2tm1Dlo/Bcl2tm1Dlo mice
mortality/aging
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• live up to 300 days due to mild polycystic kidney disease (PKD)
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growth/size/body
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• mild signs of polycystic kidney disease (PKD)
• progress slowly
• live up to 300 days
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• retarded growth
• most of these animals (n = 24) become healthy adults
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• spleens are heavier than those in homozygous Bcl-2 deficient mice
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hematopoietic system
N |
• normal splenic structure
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• less apoptosis than in homozygous Bcl-2 deficient mice spleen
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• spleens are heavier than those in homozygous Bcl-2 deficient mice
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• more white blood cells numbers than in homozygous Bcl-2 deficient mice
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renal/urinary system
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• mild signs of polycystic kidney disease (PKD)
• progress slowly
• live up to 300 days
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immune system
N |
• normal splenic structure
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• less apoptosis than in homozygous Bcl-2 deficient mice spleen
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• spleens are heavier than those in homozygous Bcl-2 deficient mice
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• more white blood cells numbers than in homozygous Bcl-2 deficient mice
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cellular
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• less apoptosis than in homozygous Bcl-2 deficient mice spleen
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm3.1Boui mutation
(0 available);
any
Bcl2l11 mutation
(32 available)
Tg(IghMyc)22Bri mutation
(1 available)
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mortality/aging
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• median lifespan is 110 days, which is similar to single Tg(IghMyc)22Bri hemizygotes
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neoplasm
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• mutants exhibit a mixture of sIg- pre-B lymphoma (~55%) and sIg+ B lymphoma (~45%)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm3.1Boui mutation
(0 available);
any
Bcl2l11 mutation
(32 available)
Tg(IghMyc)22Bri mutation
(1 available)
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mortality/aging
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• median lifespan is 84 days, which is not statistically different from single Tg(IghMyc)22Bri hemizygotes
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neoplasm
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• mutants exhibit a mix of sIg- pre-B lymphoma (~50%) and sIg+ B lymphoma (~50%)
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