Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm2.1Boui mutation
(0 available);
any
Bcl2l11 mutation
(32 available)
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hematopoietic system
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• increase in spleen weight (<2 fold)
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• increased white blood cells numbers (<2 fold)
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immune system
N |
• normal in vitro survival assays with several cytotoxic stimuli on sorted thymocyte and B cell populations
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• increase in spleen weight (<2 fold)
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• increased white blood cells numbers (<2 fold)
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growth/size/body
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• increase in spleen weight (<2 fold)
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Boui mutation
(0 available);
any
Bcl2l11 mutation
(32 available)
Bcl2l11tm2.1Boui mutation
(0 available);
any
Bcl2l11 mutation
(32 available)
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hematopoietic system
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• increase in spleen weight (<2 fold)
|
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• increased white blood cells numbers (<2 fold)
|
immune system
N |
• normal in vitro survival assays with several cytotoxic stimuli on sorted thymocyte and B cell populations
|
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• increase in spleen weight (<2 fold)
|
|
• increased white blood cells numbers (<2 fold)
|
growth/size/body
|
• increase in spleen weight (<2 fold)
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm1.1Boui mutation
(0 available);
any
Bcl2l11 mutation
(32 available)
Bcl2l11tm2.1Boui mutation
(0 available);
any
Bcl2l11 mutation
(32 available)
Bcl2tm1Dlo mutation
(0 available);
any
Bcl2 mutation
(41 available)
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BH3 replacement mutations in Bcl2l11 prevent the development of polycystic kidney disease and spleen atrophy in Bcl2tm1Dlo/Bcl2tm1Dlo mice
hematopoietic system
N |
• normal splenic structure
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• spleens are much heavier than those in homozygous Bcl-2 deficient mice
• spleens are much heavier than those in homozygous Bcl-2 deficient with only one Bcl2l1 deficient allele mice
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• white blood cells numbers are six fold more abundant than in homozygous Bcl-2 deficient mice
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renal/urinary system
N |
• mice do not develop polycystic kidney disease
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immune system
N |
• normal splenic structure
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• spleens are much heavier than those in homozygous Bcl-2 deficient mice
• spleens are much heavier than those in homozygous Bcl-2 deficient with only one Bcl2l1 deficient allele mice
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• white blood cells numbers are six fold more abundant than in homozygous Bcl-2 deficient mice
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growth/size/body
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• spleens are much heavier than those in homozygous Bcl-2 deficient mice
• spleens are much heavier than those in homozygous Bcl-2 deficient with only one Bcl2l1 deficient allele mice
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm2.1Boui mutation
(0 available);
any
Bcl2l11 mutation
(32 available)
Bcl2tm1Dlo mutation
(0 available);
any
Bcl2 mutation
(41 available)
|
|
|
BH3 replacement mutations in Bcl2l11 prevent the development of polycystic kidney disease and spleen atrophy in Bcl2tm1Dlo/Bcl2tm1Dlo mice
growth/size/body
hematopoietic system
N |
• normal splenic structure
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immune system
N |
• normal splenic structure
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renal/urinary system
N |
• mice do not develop polycystic kidney disease
diluted coat color [MP:0000371]
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pigmentation
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• coat color becomes gray at 5 to 7 weeks of age
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integument
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• coat color becomes gray at 5 to 7 weeks of age
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm2.1Boui mutation
(0 available);
any
Bcl2l11 mutation
(32 available)
Tg(IghMyc)22Bri mutation
(1 available)
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mortality/aging
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• average survival is 70 days; survival is decreased compared to single Tg(IghMyc)22Bri hemizygotes which live to about 100 days
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neoplasm
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• mutants exhibit a mixture of sIg- pre-B lymphoma (~55%) and sIg+ B lymphoma (~45%)
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hematopoietic system
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• white blood cell counts are increased to a similar extent as in single Tg(IghMyc)22Bri hemizygotes
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immune system
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• white blood cell counts are increased to a similar extent as in single Tg(IghMyc)22Bri hemizygotes
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11tm2.1Boui mutation
(0 available);
any
Bcl2l11 mutation
(32 available)
Tg(IghMyc)22Bri mutation
(1 available)
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mortality/aging
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• median survival of 58 days
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neoplasm
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• mutants exhibit a mixture of sIg- pre-B lymphoma (~60%) and sIg+ B lymphoma (~40%)
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hematopoietic system
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• increase in white blood cell count is higher than in single Tg(IghMyc)22Bri hemizygotes
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immune system
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• increase in white blood cell count is higher than in single Tg(IghMyc)22Bri hemizygotes
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