Analysis Tools
immune system
|
• doxycycline treated mice show decreased levels of inflammatory markers in the growth plate compared to Tg(Col2a1-rtTA,tetO-COMP*)2Jath/0 mice
|
|
Allele Symbol Allele Name Allele ID |
Tg(Col2a1-rtTA,tetO-COMP*)2Jath transgene insertion 2, Jacqueline Hecht MGI:4361028 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• doxycycline treated mice show decreased levels of inflammatory markers in the growth plate compared to Tg(Col2a1-rtTA,tetO-COMP*)2Jath/0 mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• doxycline exposure in the prenatal period to P7 evokes very little growth plate chondrocyte death, however doxycycline exposure in the prenatal period to P14, P21 or P28, increases growth plate chondrocyte death
|
|
• doxycycline treated mice show a reduction in the size of the skeleton by P7 and are 12% shorter at P28, at which time it is most marked
|
|
• total skull length is reduced by 10% in doxycycline treated mice
• however, intercanthal distance is normal
|
|
• exaggerated curvature in the thoracic and lumbar spine is seen in most doxycycline treated mice by P28
|
|
• doxycline exposure in the prenatal period to P14, P21, or P28 increases growth plate chondrocyte death and doxycline exposure to P21 or P28 results in increased inflammation in the growth plate
• treatment with lithium reduces pup viability and disrupts growth plate organization
• treatment of doxycycline-administered mice with valproate reduces apoptosis by about 50% and improves growth plate architecture, however skull and limb lengths are reduced by another 9%
• treatment of doxycycline-administered mice with phenylbutyric acid only minimally reduces apoptosis in the growth plate
|
|
• doxycycline-treated mice exhibit fewer hypertrophic chondrocytes compared with wild-type mice
• doxycycline-treated mice exhibit retention of extracellular matrix protein and intracellular matrix formation in the ribosomal endoplasmic reticulum cisternae in the growth plate unlike in wild-type mice
|
|
• in doxycycline-treated mice
|
|
• doxycycline-treated mice exhibit an increase in apoptosis in the growth plate compared to in wild-type mice
|
|
• doxycline exposure in the prenatal period to P7 evokes very little growth plate chondrocyte death, however doxycycline exposure in the prenatal period to P14, P21 or P28, increases growth plate chondrocyte death
|
|
• total skull length is reduced by 10% in doxycycline treated mice
• however, intercanthal distance is normal
|
|
• an increase in cartilage is seen in the snout of P21 and P28 doxycycline treated mice
|
|
• total snout length is reduced by 15% in doxycycline treated mice
|
|
• an increase in cartilage is seen in the snout of P21 and P28 doxycycline treated mice
|
|
• total snout length is reduced by 15% in doxycycline treated mice
|
|
• doxycycline treated mice show a marked progression in the development of pectus carinatum at P28
|
|
• inflammation as analyzed by markers develops in the growth plate when mice are exposed to doxycycline from conception to P21 or P28, but not when they are only exposed to it to E15.5, P1, P7 or P14
• exercise in doxycycline treated mice exacerbates inflammation in the articular cartilage
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| pseudoachondroplasia | DOID:0080047 |
OMIM:177170 |
J:152756 , J:233238 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 04/30/2024 MGI 6.23 |
|
|
|
||