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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atf4tm1Kry
targeted mutation 1, Gerard Karsenty
MGI:4360484
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Atf4tm1Kry/Atf4tm1Kry
Creb1tm3Gsc/Creb1tm3Gsc
Tg(Col1a1-cre)1Kry/0 		involves: 129P2/OlaHsd * C57BL/6J * FVB MGI:4360509
cn2
 		Atf4tm1Kry/Atf4tm1Kry
Tg(Col1a1-cre)1Kry/0 		involves: C57BL/6J * FVB MGI:4360510


Genotype
MGI:4360509
cn1
Allelic
Composition		 Atf4tm1Kry/Atf4tm1Kry
Creb1tm3Gsc/Creb1tm3Gsc
Tg(Col1a1-cre)1Kry/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf4tm1Kry mutation (0 available); any Atf4 mutation (21 available)
Creb1tm3Gsc mutation (2 available); any Creb1 mutation (59 available)
Tg(Col1a1-cre)1Kry mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:152695 )
N
• mice exhibit normal glucose and insulin homeostasis




Genotype
MGI:4360510
cn2
Allelic
Composition		 Atf4tm1Kry/Atf4tm1Kry
Tg(Col1a1-cre)1Kry/0
Genetic
Background		 involves: C57BL/6J * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf4tm1Kry mutation (0 available); any Atf4 mutation (21 available)
Tg(Col1a1-cre)1Kry mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:152695 )
N
• serum leptin, resistin, and adiponectin levels are normal
abnormal glucose homeostasis ( J:152695 )
• insulin-stimulated whole-body glucose turnover is increased 40% compared to in similarly treated wild-type mice
increased insulin secretion ( J:152695 )
• following glucose challenge
decreased circulating glucose level ( J:152695 )
• at 2 weeks and 1 month
impaired gluconeogenesis ( J:152695 )
• reduced after pyruvate challenge
abnormal glycogen homeostasis ( J:152695 )
• insulin-stimulated whole-body glycogen synthesis is increased compared to in similarly treated wild-type mice

endocrine/exocrine glands
increased insulin secretion ( J:152695 )
• following glucose challenge

growth/size/body
decreased body weight ( J:152695 )




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory