Phenotypes associated with this allele

• Allele Symbol: Gpx5^tm1115.2Arte
• Allele Name: targeted mutation 1115.2, TaconicArtemis
• Allele ID: MGI:4359923
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gpx5^tm1115.2Arte/Gpx5^tm1115.2Arte	involves: C57BL/6 * C57BL/6N	MGI:4359940

Genotype
MGI:4359940

hm1

• Allelic Composition: Gpx5^tm1115.2Arte/Gpx5^tm1115.2Arte
• Genetic Background: involves: C57BL/6 * C57BL/6N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Cauda epididymidis-retrieved spermatozoa from Gpx5^tm1115.2Arte/Gpx5^tm1115.2Arte mice suffer oxidative damage

reproductive system

abnormal sperm nucleus morphology ( J:152563 )

♂ • caput sperm DNA compaction is greater than in wild-type cells while DNA compaction in cauda sperm is less than in wild-type cells

♂ • hydrogen-peroxide treated sperm exhibit an increase in 8-hydroxy-deoxyguanosine, a marker of DNA fragmentation, compared with similarly treated wild-type sperm

♂ • malondihaldehyde, a product of lipid peroxidation, accumulates twice as much as in wild-type sperm

reduced male fertility ( J:152563 )

♂ • male mice 13 and 16 months produce litters that exhibit increased miscarriage and number of dead pups or aborted fetuses when mated with wild-type females

cellular

abnormal sperm nucleus morphology ( J:152563 )

♂ • caput sperm DNA compaction is greater than in wild-type cells while DNA compaction in cauda sperm is less than in wild-type cells

♂ • hydrogen-peroxide treated sperm exhibit an increase in 8-hydroxy-deoxyguanosine, a marker of DNA fragmentation, compared with similarly treated wild-type sperm

♂ • malondihaldehyde, a product of lipid peroxidation, accumulates twice as much as in wild-type sperm