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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Sirt1tm3Fwa
targeted mutation 3, Frederick W Alt
MGI:4359275
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Sirt1tm3Fwa/Sirt1tm3Fwa
Tg(Nes-cre)1Kln/0
involves: 129S6/SvEvTac * C57BL/6 * SJL MGI:4881924


Genotype
MGI:4881924
cn1
Allelic
Composition
Sirt1tm3Fwa/Sirt1tm3Fwa
Tg(Nes-cre)1Kln/0
Genetic
Background
involves: 129S6/SvEvTac * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sirt1tm3Fwa mutation (1 available); any Sirt1 mutation (51 available)
Tg(Nes-cre)1Kln mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• reduced body weight beginning at 4-5 wk of age
• indistinguishable at birth and for their first month of life
• reduced snout-anus body length at 10 wk of age
• normal food consumption

homeostasis/metabolism
• slight reduction in fasting blood glucose levels in 10-week old mice
• reduced levels of blood glucose throughout the insulin tolerance test (ITT)
• similar performance in glucose tolerance tests, compared with wild-type littermate controls at 3 months of age
• increased serum prolactin
• trend toward a reduction in fasted insulin levels in 10-week old mice
• similar performance in insulin tolerance tests, compared with wild-type littermate controls at 3 months of age
• lower serum insulin-like growth factor I (IGF-1) levels in 10-wk-old mice than in wild-type littermate controls
• no change in serum IGF-1 levels, versus lowered serum IGF-1 levels in wild type after 10 wk of calorie restriction (CR)
• nearly 50% lower serum growth hormone (GH) levels in 4-wk-old mice than in wild-type littermate controls
• normal serum concentrations of adrenocorticotropic hormone, thyroid-stimulating hormone, T3, and T4
• old mice (10 months) display glucose intolerance
• produce more insulin in response to glucose injection than wild type at 10 months old
• By ITT, high-fat-fed mice appear to remain somewhat more insulin-sensitive than wild-type mice fed the same diet
• CR induces only a modest improvement in insulin sensitivity

endocrine/exocrine glands
• smaller pituitaries than those of wild-type littermates
• no major defects upon histological examination
• normal density of GH positive cells
• reduced mass of the pituitaries normalized to body mass of 10-wk-old mice
• each pituitary gland contained significantly less stored GH

behavior/neurological
• more active (on running wheels) than wild-type animals on an ad libitum diet
• no increase and slightly decreased physical activity, versus dramatically up-regulated activity in wild-type animals after 7 mo of CR

nervous system
• smaller pituitaries than those of wild-type littermates
• no major defects upon histological examination
• normal density of GH positive cells
• reduced mass of the pituitaries normalized to body mass of 10-wk-old mice
• each pituitary gland contained significantly less stored GH





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory