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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(TXNRD2,COMT,ARVCF)1Nhir
transgene insertion 1, Noboru Hiroi
MGI:4358257
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
tg1
Tg(TXNRD2,COMT,ARVCF)1Nhir/0 B6.FVB-Tg(TXNRD2,COMT,ARVCF)1Nhir MGI:4358324


Genotype
MGI:4358324
tg1
Allelic
Composition
Tg(TXNRD2,COMT,ARVCF)1Nhir/0
Genetic
Background
B6.FVB-Tg(TXNRD2,COMT,ARVCF)1Nhir
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(TXNRD2,COMT,ARVCF)1Nhir mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• social behavior, anxiety-related responses, thigmotaxis, immobility on suspension by the tail and startle reflex are not different from controls
• mice show a tendency toward lower levels of motor activity compared to wild-type controls but differences were not significant at 1, 2, or 5 months
• mutants show shorter latency to reach a rewarded arm on an L maze (enhanced incentive learning) on initial 4 days of training compared to wild-type mice at 1 and 2 months of age
• in a rewarded alternation paradigm, mutants and wild-type showed equivalent performance but in a delayed rewarded alternation test, mutants show impaired performance at 2 months of age, but not at 1 month in contrast to wild-type mice which showed improved performance at 2 months
• mice show impaired performance in delayed reward alternation, suggesting a deficit in spatial working memory; short term retention of working memory is normal

homeostasis/metabolism
• catechol-O-methyltransferase activity is around 2-fold higher in the prefrontal cortex, hippocampus, and striatum than in wild-type controls

nervous system
N
• at 5 months of age prepulse inhibition is not different from controls





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/18/2022
MGI 6.17
The Jackson Laboratory