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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Slc4a1tm1Phsl
targeted mutation 1, Philip S Low
MGI:4357799
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Slc4a1tm1Phsl/Slc4a1tm1Phsl involves: 129 * 129S6/SvEvTac * Black Swiss MGI:4357833
ht2
 		Slc4a1tm1Phsl/Slc4a1+ involves: 129 * 129S6/SvEvTac * Black Swiss MGI:4357834


Genotype
MGI:4357833
hm1
Allelic
Composition		 Slc4a1tm1Phsl/Slc4a1tm1Phsl
Genetic
Background		 involves: 129 * 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc4a1tm1Phsl mutation (0 available); any Slc4a1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:152245 )
• only 80% of mice survive until weaning

hematopoietic system
enlarged spleen ( J:152245 )
• mice have massive splenomegaly
abnormal erythrocyte morphology ( J:152245 )
• red blood cell lifespan is 2 days compared to 60 in controls
low mean erythrocyte cell number ( J:152245 )
• there is over a 60% drop in mean erythrocyte cell number
decreased hematocrit ( J:152245 )
• hematocrit is decreased by half
decreased hemoglobin content ( J:152245 )
• hemoglobin is decreased by more than half
increased mean corpuscular volume ( J:152245 )
• corpuscular volume is increased by 20%
increased nucleated erythrocyte cell number ( J:152245 )
• 69 x 103 nucleated RBC per liter are found in the blood
thrombocytopenia ( J:152245 )
• platelet counts are about 40% of normal
reticulocytosis ( J:152245 )
• reticulocyte percentage is increased almost 50-fold in the blood

immune system
enlarged spleen ( J:152245 )
• mice have massive splenomegaly

integument
pallor ( J:152245 )
• homozygote newborns are easily distinguishable from controls by their extreme pallor

growth/size/body
enlarged spleen ( J:152245 )
• mice have massive splenomegaly




Genotype
MGI:4357834
ht2
Allelic
Composition		 Slc4a1tm1Phsl/Slc4a1+
Genetic
Background		 involves: 129 * 129S6/SvEvTac * Black Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc4a1tm1Phsl mutation (0 available); any Slc4a1 mutation (54 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
reticulocytosis ( J:152245 )
• reticulocyte percentage is increased 3-fold in the blood




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory