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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Atp1a3)1Stcl
transgene insertion 1, Steven J Clapcote
MGI:4356322
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Atp1a3Myk/Atp1a3+
Tg(Atp1a3)1Stcl/0 		B6NCr.Cg-Atp1a3Myk Tg(Atp1a3)1Stcl MGI:6163488
cx2
 		Atp1a3Myk/Atp1a3+
Tg(Atp1a3)1Stcl/0 		involves: 129S1/SvImJ * C57BL/6 * SJL MGI:4356323
tg3
 		Tg(Atp1a3)1Stcl/0 B6NCr.Cg-Tg(Atp1a3)1Stcl/Stcl MGI:6163486


Genotype
MGI:6163488
cx1
Allelic
Composition		 Atp1a3Myk/Atp1a3+
Tg(Atp1a3)1Stcl/0
Genetic
Background		 B6NCr.Cg-Atp1a3Myk Tg(Atp1a3)1Stcl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a3Myk mutation (2 available); any Atp1a3 mutation (68 available)
Tg(Atp1a3)1Stcl mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:262367 )
N
• unlike Atp1a3Myk heterozygotes, mice exhibit normal coordination and contextual fear conditioning
abnormal behavior ( J:262367 )
• mice take longer to find a hidden platform and swim further compared with wild-type mice
• however, swim speed and floating is normal
increased thigmotaxis ( J:262367 )
• in a Morris water maze due to reduced behavioral flexibility

growth/size/body
growth/size/body region phenotype ( J:262367 )
N
• unlike Atp1a3Myk heterozygotes, mice exhibit normal body weight




Genotype
MGI:4356323
cx2
Allelic
Composition		 Atp1a3Myk/Atp1a3+
Tg(Atp1a3)1Stcl/0
Genetic
Background		 involves: 129S1/SvImJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp1a3Myk mutation (2 available); any Atp1a3 mutation (68 available)
Tg(Atp1a3)1Stcl mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:151948 )
N
• cage shaking does not induce seizures as it does for Atp1a3Myk heterozygotes

behavior/neurological
behavior/neurological phenotype ( J:180250 )
N
• mice perform at normal levels in the open field, elevated plus maze and light-dark box




Genotype
MGI:6163486
tg3
Allelic
Composition		 Tg(Atp1a3)1Stcl/0
Genetic
Background		 B6NCr.Cg-Tg(Atp1a3)1Stcl/Stcl
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal behavior ( J:262367 )
• mice exhibit normal performance in a Morris water maze and contextual fear conditioning
increased freezing behavior ( J:262367 )
• mice exhibit increased baseline freezing before foot shock administration in a contextual fear conditioning




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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory