All Phenotypes Fgf21<tm1.1Djm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Fgf21^tm1.1Djm
targeted mutation 1.1, David J Mangelsdorf
MGI:4354163

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgf21^tm1.1Djm/Fgf21^tm1.1Djm	involves: 129S6/SvEvTac * C57BL/6	MGI:4354176

Allelic Composition	Fgf21^tm1.1Djm/Fgf21^tm1.1Djm
Genetic Background	involves: 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fgf21^tm1.1Djm mutation (1 available); any Fgf21 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating glucose level ( J:150831 )

• in fasted mice

hypoglycemia ( J:150831 )

decreased circulating ketone body level ( J:150831 )

• in fed mice

decreased oxygen consumption ( J:150831 )

• in fasted mice

abnormal gluconeogenesis ( J:150831 )

• in response to fasting, mice fail to display increased gluconeogenesis in the liver as in wild-type mice

decreased physiological sensitivity to xenobiotic ( J:150831 )

• treatment with octanoate only increased plasma beta-hydroxybutyrate concentrations by 20% compared to the doubling observed in similarly treated wild-type mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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