Phenotypes associated with this allele

• Allele Symbol: Srr^rgsc1872
• Allele Name: RIKEN Genomic Sciences Center (GSC), 1872
• Allele ID: MGI:4354162
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Srr^rgsc1872/Srr^rgsc1872	C57BL/6JJcl-Srr^rgsc1872	MGI:4354165

Genotype
MGI:4354165

hm1

• Allelic Composition: Srr^rgsc1872/Srr^rgsc1872
• Genetic Background: C57BL/6JJcl-Srr^rgsc1872

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal spatial reference memory ( J:151337 )

• however, response to introduction of a novel object is similar to controls

• in a spatial object recognition assay mice fail to spend more time investigating displaced objects relative to non-displaced objects unlike controls

• treatment with D-serine or clozapine improves performance

abnormal long-term spatial reference memory ( J:151337 )

• impaired performance in a Morris water maze probe trial conducted 5 days after training

induced hyperactivity ( J:151337 )

• hyperactivity induced by MJ-801 is significantly greater compared to controls

abnormal social investigation ( J:151337 )

• mice do no prefer the chamber with an unfamiliar conspecific mouse over the empty chamber in a sociability assay

• but, mice perform normally in a social novelty assay and no defects in exploratory behavior or olfactory function were detected

• treatment with D-serine, but not with clozapine, reversed the social behavior defect

homeostasis/metabolism

decreased serine level ( J:151337 )

• D-serine levels are markedly reduced in the whole brain, hippocampus, and frontal cortex, but not in the cerebellum

increased serine level ( J:151337 )

• in the frontal cortex L-serine levels are increased

nervous system

decreased prepulse inhibition ( J:151337 )

• decreased prepulse inhibition

• responses to startle stimuli are normal in the absence of prepulse signal

• treatment with D-serine or clozapine rescued the prepulse inhibition defect

• treatment with MK-801 induces a greater impairment in prepulse inhibition compared to similarly treated controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
schizophrenia		DOID:5419	OMIM:181500	J:151337