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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ets2tm5.1Rgo
targeted mutation 5.1, Robert G Oshima
MGI:4353393
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ets2tm5.1Rgo/Ets2tm5.1Rgo
Meox2tm1(cre)Sor/Meox2+ 		involves: 129/Sv * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:4353413
cn2
 		Ets1tm1Jml/Ets1tm1Jml
Ets2tm5.1Rgo/Ets2tm5.1Rgo
Meox2tm1(cre)Sor/Meox2+ 		involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N MGI:4353414
cn3
 		Ets1tm1Jml/Ets1tm1Jml
Ets2tm5.1Rgo/Ets2tm5.1Rgo
Tg(Tek-cre)1Ywa/0 		involves: 129S/SvEv * C57BL/6 * FVB/N MGI:4353416
cn4
 		Ets2tm1Rgo/Ets2tm5.1Rgo
Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(S100a4-cre)1Gle/0 		involves: 129S2/SvPas * FVB/N MGI:4366764
cn5
 		Ets2tm1Rgo/Ets2tm5.1Rgo
Tg(MMTV-PyVT)634Mul/0
Tg(S100a4-cre)1Gle/0 		involves: 129S2/SvPas * FVB/N MGI:4366767
cn6
 		Ets2tm1Rgo/Ets2tm5.1Rgo
Tg(S100a4-cre)1Gle/0 		involves: 129S2/SvPas * FVB/N MGI:4366768


Genotype
MGI:4353413
cn1
Allelic
Composition		 Ets2tm5.1Rgo/Ets2tm5.1Rgo
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129/Sv * 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (37 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:151187 )
N
• viable unlike homozygous null mice

integument




Genotype
MGI:4353414
cn2
Allelic
Composition		 Ets1tm1Jml/Ets1tm1Jml
Ets2tm5.1Rgo/Ets2tm5.1Rgo
Meox2tm1(cre)Sor/Meox2+
Genetic
Background		 involves: 129S/SvEv * 129S4/SvJaeSor * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1tm1Jml mutation (0 available); any Ets1 mutation (25 available)
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (37 available)
Meox2tm1(cre)Sor mutation (3 available); any Meox2 mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:151187 )
• die between E11.5 and E15.5

cardiovascular system
hemorrhage ( J:151187 )
• seen at E11.5 in some embryos

homeostasis/metabolism
edema ( J:151187 )
• seen at E11.5 in some embryos




Genotype
MGI:4353416
cn3
Allelic
Composition		 Ets1tm1Jml/Ets1tm1Jml
Ets2tm5.1Rgo/Ets2tm5.1Rgo
Tg(Tek-cre)1Ywa/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets1tm1Jml mutation (0 available); any Ets1 mutation (25 available)
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (37 available)
Tg(Tek-cre)1Ywa mutation (6 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cellular
increased vascular endothelial cell apoptosis ( J:151187 )
• increase in endothelial cell apoptosis at E11.5 and E13.5

cardiovascular system
abnormal vascular branching morphogenesis ( J:151187 )
• defect in branching seen at E10.5 and E11.5
• increase in inter blood vessel spacing
increased vascular endothelial cell apoptosis ( J:151187 )
• increase in endothelial cell apoptosis at E11.5 and E13.5




Genotype
MGI:4366764
cn4
Allelic
Composition		 Ets2tm1Rgo/Ets2tm5.1Rgo
Ptentm1.1Mwst/Ptentm1.1Mwst
Tg(S100a4-cre)1Gle/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm1Rgo mutation (1 available); any Ets2 mutation (37 available)
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (37 available)
Ptentm1.1Mwst mutation (0 available); any Pten mutation (81 available)
Tg(S100a4-cre)1Gle mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased mammary gland tumor incidence ( J:153747 )
• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(S100a4-cre)1Gle mice
increased mammary gland tumor incidence ( J:153747 )
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes
abnormal tumor morphology ( J:153747 )
• mammary tumors induced by NT2.5 exhibit decreased numbers of macrophages and recruitment of new vasculature compared to in similarly treated Ptentm1.1Mwst homozygotes

integument
decreased mammary gland tumor incidence ( J:153747 )
• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(S100a4-cre)1Gle mice
increased mammary gland tumor incidence ( J:153747 )
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes

endocrine/exocrine glands
decreased mammary gland tumor incidence ( J:153747 )
• fewer and smaller tumors form in mice injected with the mammary tumor line NT2.5 compared to in similarly treated Ptentm1.1Mwst/Ptentm1.1Mwst Tg(S100a4-cre)1Gle mice
increased mammary gland tumor incidence ( J:153747 )
• mice injected with the mammary tumor line NT2.5 develop more mammary tumors than in similarly treated Ptentm1.1Mwst homozygotes




Genotype
MGI:4366767
cn5
Allelic
Composition		 Ets2tm1Rgo/Ets2tm5.1Rgo
Tg(MMTV-PyVT)634Mul/0
Tg(S100a4-cre)1Gle/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm1Rgo mutation (1 available); any Ets2 mutation (37 available)
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (37 available)
Tg(MMTV-PyVT)634Mul mutation (2 available)
Tg(S100a4-cre)1Gle mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
decreased mammary gland tumor incidence ( J:153747 )
• fewer mammary tumors form than in Ets2tm1Rgo/Ets2tm5.1Rgo Tg(MMTV-PyVT)634Mul mice and progression to adenoma and early carcinoma is slowed

integument
decreased mammary gland tumor incidence ( J:153747 )
• fewer mammary tumors form than in Ets2tm1Rgo/Ets2tm5.1Rgo Tg(MMTV-PyVT)634Mul mice and progression to adenoma and early carcinoma is slowed

endocrine/exocrine glands
decreased mammary gland tumor incidence ( J:153747 )
• fewer mammary tumors form than in Ets2tm1Rgo/Ets2tm5.1Rgo Tg(MMTV-PyVT)634Mul mice and progression to adenoma and early carcinoma is slowed




Genotype
MGI:4366768
cn6
Allelic
Composition		 Ets2tm1Rgo/Ets2tm5.1Rgo
Tg(S100a4-cre)1Gle/0
Genetic
Background		 involves: 129S2/SvPas * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ets2tm1Rgo mutation (1 available); any Ets2 mutation (37 available)
Ets2tm5.1Rgo mutation (0 available); any Ets2 mutation (37 available)
Tg(S100a4-cre)1Gle mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
endocrine/exocrine gland phenotype ( J:153747 )
N
• mice exhibit normal mammary gland development




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory