Phenotypes associated with this allele

• Allele Symbol: Foxp2^tm1Woen
• Allele Name: targeted mutation 1, Wolfgang Enard
• Allele ID: MGI:3851106
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxp2^tm1Woen/Foxp2^tm1Woen	involves: C57BL/6 * C57BL/6J	MGI:3851146

Genotype
MGI:3851146

hm1

• Allelic Composition: Foxp2^tm1Woen/Foxp2^tm1Woen
• Genetic Background: involves: C57BL/6 * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

decreased exploration in new environment ( J:150425 )

• on a modified hole board

decreased locomotor activity ( J:150425 )

• mice exhibit less forward locomotor activity compared with wild-type mice

decreased vocalization ( J:150425 )

• start peak frequency, mean, minimum, and maximum of calls less than 50 ms are lower than in wild-type mice

• the slope of calls less than 50 ms declines less in frequency and locally less modulated compared to in wild-type mice

• amplitude gap, duration, peak frequency minimum, and peak frequency start are increased in calls with frequency jumps compared to in wild-type mice

cardiovascular system

decreased QRS amplitude ( J:150425 )

• mice exhibit lower R-wave amplitudes compared with wild-type mice