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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Apctm1.1Rsmi
targeted mutation 1.1, Ron Smits
MGI:3848480
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Apctm1.1Rsmi/Apc+ involves: 129P2/OlaHsd MGI:3848498
ht2
 		Apctm1.1Rsmi/Apc+ involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:4456427


Genotype
MGI:3848498
ht1
Allelic
Composition		 Apctm1.1Rsmi/Apc+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1.1Rsmi mutation (0 available); any Apc mutation (154 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased gastrointestinal tumor incidence ( J:149225 )
• mice develop multiple intestinal tumors at an early age

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:149225 )
• mice develop multiple intestinal tumors at an early age




Genotype
MGI:4456427
ht2
Allelic
Composition		 Apctm1.1Rsmi/Apc+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apctm1.1Rsmi mutation (0 available); any Apc mutation (154 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
skin cyst ( J:159883 )
• very few cutaneous cysts are observed unlike in wild-type mice

mortality/aging
premature death ( J:159883 )
• primarily due to intestinal obstruction

neoplasm
increased gastrointestinal tumor incidence ( J:159883 )
• mice develop intestinal tumors primarily in the small intestine unlike wild-type mice
increased large intestine adenocarcinoma incidence ( J:159883 )
• mice develop intestinal tumors primarily in the small intestine unlike wild-type mice
increased small intestine adenocarcinoma incidence ( J:159883 )
• mice develop intestinal tumors primarily in the small intestine unlike wild-type mice
increased intestinal adenoma incidence ( J:159883 )
• polyp or flat adenoma
increased desmoid tumor incidence ( J:159883 )
• mice develop infrequent desmoid tumors

digestive/alimentary system
increased gastrointestinal tumor incidence ( J:159883 )
• mice develop intestinal tumors primarily in the small intestine unlike wild-type mice
increased large intestine adenocarcinoma incidence ( J:159883 )
• mice develop intestinal tumors primarily in the small intestine unlike wild-type mice
increased small intestine adenocarcinoma incidence ( J:159883 )
• mice develop intestinal tumors primarily in the small intestine unlike wild-type mice
increased intestinal adenoma incidence ( J:159883 )
• polyp or flat adenoma

hematopoietic system
anemia ( J:159883 )
• severe

integument
skin cyst ( J:159883 )
• very few cutaneous cysts are observed unlike in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory