All Phenotypes Dclk2<tm1.2Jgg> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg Dcx^tm1Caw/Dcx^tm1Caw	involves: 129/Sv * C57BL/6	MGI:3844814
cx2	Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg Dcx^tm1Caw/Y	involves: 129/Sv * C57BL/6	MGI:3844816

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:148345 )

• less than 10% of mice survive to 5 months of age

postnatal lethality, incomplete penetrance ( J:148345 )

• about half the die mice before weaning

behavior/neurological

convulsive seizures ( J:148345 )

• repetitive epileptiform discharges from the hippocampus consisting of 4-Hz monomorphic spike activity are observed in mice prior to seizures

• at the onset of the convulsive attack, hippocampus activity increases from 400 microV up to 1 mV, and then transitions into spike and wave appearance at 3-Hz frequency

• these spikes in activity transmit to the cortex about half the time leading to tonic-clonic convulsions

tonic-clonic seizures ( J:148345 )

• as early as P16, mice have spontaneous seizures often accompanied by behavioral arrest and forelimb myoclonus

• seizures originate in the hippocampus with spikes in activity that half the time transmit to the cortex and cause tonic-clonic seizures

nervous system

convulsive seizures ( J:148345 )

• repetitive epileptiform discharges from the hippocampus consisting of 4-Hz monomorphic spike activity are observed in mice prior to seizures

• at the onset of the convulsive attack, hippocampus activity increases from 400 microV up to 1 mV, and then transitions into spike and wave appearance at 3-Hz frequency

• these spikes in activity transmit to the cortex about half the time leading to tonic-clonic convulsions

tonic-clonic seizures ( J:148345 )

• as early as P16, mice have spontaneous seizures often accompanied by behavioral arrest and forelimb myoclonus

• seizures originate in the hippocampus with spikes in activity that half the time transmit to the cortex and cause tonic-clonic seizures

abnormal brain interneuron morphology ( J:148345 )

• CaBP+ interneurons that interact with pyramidal neurons are improperly laminated within the stratum radiatum-lacunosum moleculare border

abnormal dentate gyrus morphology ( J:148345 )

• mice have reduced packing density of the dentate granule neuron layer, resulting in an increased thickness

abnormal hippocampal mossy fiber morphology ( J:148345 )

• mossy fibers fail to separate into the infrapyramidal and the suprapyrimidal bundles and, as a result, mossy fibers travel aberrantly within the pyramidal layer

abnormal hippocampus granule cell layer ( J:148345 )

• lamination density of the granule cell layer is increased in these mice

abnormal hippocampus pyramidal cell morphology ( J:148345 )

• pyramidal neurons displayed a striking simplification of apical dendritic arbors with decreased branching from both primary and secondary apical dendrites

abnormal hippocampus region morphology ( J:148345 )

• about half of the somatostatin neurons are selectively lost in the hippocampus by day 18 after birth

abnormal hippocampus CA1 region morphology ( J:148345 )

• about 40% of neurons are displaced into the stratum oriens

abnormal hippocampus CA3 region morphology ( J:148345 )

• the CA3 region is dyslaminated with a small percentage of neurons heterotopically located in the stratum oriens

abnormal inhibitory postsynaptic currents ( J:148345 )

• the frequency of spontaneous sIPSC among pyramidal neurons is severely reduced by 55% compared to controls

Allelic Composition	Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg Dcx^tm1Caw/Y
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk2^tm1.2Jgg mutation (1 available); any Dclk2 mutation (134 available)
Dcx^tm1Caw mutation (0 available); any Dcx mutation (18 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Hippocampal disorganization, increased c-fos, and loss of SOM+ interneurons in Dcx^tm1Caw/Y Dclk2^tm1.2Jgg/Dclk2^tm1.2Jgg mice

mortality/aging

premature death ( J:148345 )

• less than 10% of mice survive to 5 months of age

postnatal lethality, incomplete penetrance ( J:148345 )

• about half the die mice before weaning

behavior/neurological

convulsive seizures ( J:148345 )

• repetitive epileptiform discharges from the hippocampus consisting of 4-Hz monomorphic spike activity are observed in mice prior to seizures

• at the onset of the convulsive attack, hippocampus activity increases from 400 microV up to 1 mV, and then transitions into spike and wave appearance at 3-Hz frequency

• these spikes in activity transmit to the cortex about half the time leading to tonic-clonic convulsions

tonic-clonic seizures ( J:148345 )

• as early as P16, mice have spontaneous seizures often accompanied by behavioral arrest and forelimb myoclonus

• seizures originate in the hippocampus with spikes in activity that half the time transmit to the cortex and cause tonic-clonic seizures

nervous system

convulsive seizures ( J:148345 )

• repetitive epileptiform discharges from the hippocampus consisting of 4-Hz monomorphic spike activity are observed in mice prior to seizures

• at the onset of the convulsive attack, hippocampus activity increases from 400 microV up to 1 mV, and then transitions into spike and wave appearance at 3-Hz frequency

• these spikes in activity transmit to the cortex about half the time leading to tonic-clonic convulsions

tonic-clonic seizures ( J:148345 )

• as early as P16, mice have spontaneous seizures often accompanied by behavioral arrest and forelimb myoclonus

• seizures originate in the hippocampus with spikes in activity that half the time transmit to the cortex and cause tonic-clonic seizures

abnormal brain interneuron morphology ( J:148345 )

• CaBP+ interneurons that interact with pyramidal neurons are improperly laminated within the stratum radiatum-lacunosum moleculare border

abnormal dentate gyrus morphology ( J:148345 )

• mice have reduced packing density of the dentate granule neuron layer, resulting in an increased thickness

abnormal hippocampal mossy fiber morphology ( J:148345 )

• mossy fibers fail to separate into the infrapyramidal and the suprapyrimidal bundles and, as a result, mossy fibers travel aberrantly within the pyramidal layer

abnormal hippocampus granule cell layer ( J:148345 )

• lamination density of the granule cell layer is increased in these mice

abnormal hippocampus pyramidal cell morphology ( J:148345 )

• pyramidal neurons displayed a striking simplification of apical dendritic arbors with decreased branching from both primary and secondary apical dendrites

abnormal hippocampus region morphology ( J:148345 )

• about half of the somatostatin neurons are selectively lost in the hippocampus by day 18 after birth

abnormal hippocampus CA1 region morphology ( J:148345 )

• about 40% of neurons are displaced into the stratum oriens

abnormal hippocampus CA3 region morphology ( J:148345 )

• the CA3 region is dyslaminated with a small percentage of neurons heterotopically located in the stratum oriens

abnormal inhibitory postsynaptic currents ( J:148345 )

• the frequency of spontaneous sIPSC among pyramidal neurons is severely reduced by 55% compared to controls

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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