About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Dclk2tm1.2Jgg
targeted mutation 1.2, Joseph G Gleeson
MGI:3844726
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Dclk2tm1.2Jgg/Dclk2tm1.2Jgg
Dcxtm1Caw/Dcxtm1Caw
involves: 129/Sv * C57BL/6 MGI:3844814
cx2
Dclk2tm1.2Jgg/Dclk2tm1.2Jgg
Dcxtm1Caw/Y
involves: 129/Sv * C57BL/6 MGI:3844816


Genotype
MGI:3844814
cx1
Allelic
Composition
Dclk2tm1.2Jgg/Dclk2tm1.2Jgg
Dcxtm1Caw/Dcxtm1Caw
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk2tm1.2Jgg mutation (1 available); any Dclk2 mutation (119 available)
Dcxtm1Caw mutation (0 available); any Dcx mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• less than 10% of mice survive to 5 months of age
• about half the die mice before weaning

behavior/neurological
• repetitive epileptiform discharges from the hippocampus consisting of 4-Hz monomorphic spike activity are observed in mice prior to seizures
• at the onset of the convulsive attack, hippocampus activity increases from 400 microV up to 1 mV, and then transitions into spike and wave appearance at 3-Hz frequency
• these spikes in activity transmit to the cortex about half the time leading to tonic-clonic convulsions
• as early as P16, mice have spontaneous seizures often accompanied by behavioral arrest and forelimb myoclonus
• seizures originate in the hippocampus with spikes in activity that half the time transmit to the cortex and cause tonic-clonic seizures

nervous system
• repetitive epileptiform discharges from the hippocampus consisting of 4-Hz monomorphic spike activity are observed in mice prior to seizures
• at the onset of the convulsive attack, hippocampus activity increases from 400 microV up to 1 mV, and then transitions into spike and wave appearance at 3-Hz frequency
• these spikes in activity transmit to the cortex about half the time leading to tonic-clonic convulsions
• as early as P16, mice have spontaneous seizures often accompanied by behavioral arrest and forelimb myoclonus
• seizures originate in the hippocampus with spikes in activity that half the time transmit to the cortex and cause tonic-clonic seizures
• CaBP+ interneurons that interact with pyramidal neurons are improperly laminated within the stratum radiatum-lacunosum moleculare border
• mice have reduced packing density of the dentate granule neuron layer, resulting in an increased thickness
• mossy fibers fail to separate into the infrapyramidal and the suprapyrimidal bundles and, as a result, mossy fibers travel aberrantly within the pyramidal layer
• lamination density of the granule cell layer is increased in these mice
• pyramidal neurons displayed a striking simplification of apical dendritic arbors with decreased branching from both primary and secondary apical dendrites
• about half of the somatostatin neurons are selectively lost in the hippocampus by day 18 after birth
• about 40% of neurons are displaced into the stratum oriens
• the CA3 region is dyslaminated with a small percentage of neurons heterotopically located in the stratum oriens
• the frequency of spontaneous sIPSC among pyramidal neurons is severely reduced by 55% compared to controls




Genotype
MGI:3844816
cx2
Allelic
Composition
Dclk2tm1.2Jgg/Dclk2tm1.2Jgg
Dcxtm1Caw/Y
Genetic
Background
involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dclk2tm1.2Jgg mutation (1 available); any Dclk2 mutation (119 available)
Dcxtm1Caw mutation (0 available); any Dcx mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Hippocampal disorganization, increased c-fos, and loss of SOM+ interneurons in Dcxtm1Caw/Y Dclk2tm1.2Jgg/Dclk2tm1.2Jgg mice

mortality/aging
• less than 10% of mice survive to 5 months of age
• about half the die mice before weaning

behavior/neurological
• repetitive epileptiform discharges from the hippocampus consisting of 4-Hz monomorphic spike activity are observed in mice prior to seizures
• at the onset of the convulsive attack, hippocampus activity increases from 400 microV up to 1 mV, and then transitions into spike and wave appearance at 3-Hz frequency
• these spikes in activity transmit to the cortex about half the time leading to tonic-clonic convulsions
• as early as P16, mice have spontaneous seizures often accompanied by behavioral arrest and forelimb myoclonus
• seizures originate in the hippocampus with spikes in activity that half the time transmit to the cortex and cause tonic-clonic seizures

nervous system
• repetitive epileptiform discharges from the hippocampus consisting of 4-Hz monomorphic spike activity are observed in mice prior to seizures
• at the onset of the convulsive attack, hippocampus activity increases from 400 microV up to 1 mV, and then transitions into spike and wave appearance at 3-Hz frequency
• these spikes in activity transmit to the cortex about half the time leading to tonic-clonic convulsions
• as early as P16, mice have spontaneous seizures often accompanied by behavioral arrest and forelimb myoclonus
• seizures originate in the hippocampus with spikes in activity that half the time transmit to the cortex and cause tonic-clonic seizures
• CaBP+ interneurons that interact with pyramidal neurons are improperly laminated within the stratum radiatum-lacunosum moleculare border
• mice have reduced packing density of the dentate granule neuron layer, resulting in an increased thickness
• mossy fibers fail to separate into the infrapyramidal and the suprapyrimidal bundles and, as a result, mossy fibers travel aberrantly within the pyramidal layer
• lamination density of the granule cell layer is increased in these mice
• pyramidal neurons displayed a striking simplification of apical dendritic arbors with decreased branching from both primary and secondary apical dendrites
• about half of the somatostatin neurons are selectively lost in the hippocampus by day 18 after birth
• about 40% of neurons are displaced into the stratum oriens
• the CA3 region is dyslaminated with a small percentage of neurons heterotopically located in the stratum oriens
• the frequency of spontaneous sIPSC among pyramidal neurons is severely reduced by 55% compared to controls





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/12/2022
MGI 6.17
The Jackson Laboratory