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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Atf2tm1Sis
targeted mutation 1, Shunsuke Ishii
MGI:3842320
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Atf2tm1Sis/Atf2tm1Sis either: (involves: C57BL/6 * CBA) or (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR) MGI:3842387
ht2
 		Atf2tm1Glm/Atf2tm1Sis involves: 129S2/SvPas * C57BL/6 * CBA MGI:3842393
cx3
 		Atf2tm1Sis/Atf2tm1Sis
Creb5tm1Sis/Creb5tm1Sis 		involves: C57BL/6 * CBA MGI:4421138
cx4
 		Atf2tm1Sis/Atf2+
Creb5tm1Sis/Creb5+ 		involves: C57BL/6 * CBA MGI:4421139


Genotype
MGI:3842387
hm1
Allelic
Composition		 Atf2tm1Sis/Atf2tm1Sis
Genetic
Background		 either: (involves: C57BL/6 * CBA) or (involves: BALB/c * C57BL/6 * CBA) or (involves: C57BL/6 * CBA * ICR)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf2tm1Sis mutation (2 available); any Atf2 mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Respiration defects of the Atf2tm1Glm/Atf2tm1Glm mice

mortality/aging
neonatal lethality, complete penetrance ( J:55657 )
• die shortly after birth

respiratory system
abnormal lung morphology ( J:55657 )
• presence of meconium in the alveoli, indicating that prenatal aspiration of the amniotic fluid containing meconium occurred
• however, histology shows normal architecture of the lung
respiratory failure ( J:55657 )
• severe respiratory distress resulting in death

embryo
abnormal placenta vasculature ( J:55657 )
• network of embryonic vessels and maternal sinuses in the placenta is poorly developed and fibrinoid accumulates around the fetal blood vessels
abnormal placenta labyrinth morphology ( J:55657 )
• number of cytotrophoblasts is lower in the labyrinth region of the placenta, although the size of the region is similar to wild-type

homeostasis/metabolism
hypoxia ( J:55657 )
• marker analysis indicates hypoxia in mutants

cardiovascular system
abnormal placenta vasculature ( J:55657 )
• network of embryonic vessels and maternal sinuses in the placenta is poorly developed and fibrinoid accumulates around the fetal blood vessels

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
meconium aspiration syndrome DOID:11049 J:55657




Genotype
MGI:3842393
ht2
Allelic
Composition		 Atf2tm1Glm/Atf2tm1Sis
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf2tm1Glm mutation (1 available); any Atf2 mutation (89 available)
Atf2tm1Sis mutation (2 available); any Atf2 mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

respiratory system




Genotype
MGI:4421138
cx3
Allelic
Composition		 Atf2tm1Sis/Atf2tm1Sis
Creb5tm1Sis/Creb5tm1Sis
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf2tm1Sis mutation (2 available); any Atf2 mutation (89 available)
Creb5tm1Sis mutation (1 available); any Creb5 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cell differentiation ( J:156376 )
• MEFs display reduced adipocyte differentiation compared to double heterozygous cells and wild-type cells
• overexpression of PPARG rescues the defect in adipocyte differentiation in MEFs




Genotype
MGI:4421139
cx4
Allelic
Composition		 Atf2tm1Sis/Atf2+
Creb5tm1Sis/Creb5+
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atf2tm1Sis mutation (2 available); any Atf2 mutation (89 available)
Creb5tm1Sis mutation (1 available); any Creb5 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
adipose tissue
adipose tissue phenotype ( J:156376 )
N
• unlike in white adipose tissue, no defects are detected in the brown adipose tissue
decreased subcutaneous adipose tissue amount ( J:156376 )
• decrease in the weight of subcutaneous WAT relative to total body weight compared to wild-type controls
decreased white adipose tissue amount ( J:156376 )
• decrease in WAT weight compared to wild-type controls
• decrease in the weight of visceral WAT relative to total body weight compared to wild-type controls

homeostasis/metabolism
improved glucose tolerance ( J:156376 )
• display less high fat diet induced hyperglycemia in an intraperitoneal glucose tolerance test
increased insulin sensitivity ( J:156376 )
• hypoglycemic response to insulin is increased compared to wild-type controls

cellular
abnormal cell differentiation ( J:156376 )
• MEFs display reduced adipocyte differentiation compared to wild-type cells

behavior/neurological
behavior/neurological phenotype ( J:156376 )
N
• despite the decrease in white adipose tissue weight, no difference in cumulative food intake is detected

growth/size/body
growth/size/body region phenotype ( J:156376 )
N
• despite the decrease in white adipose tissue weight, no difference in total body weight is detected

integument
decreased subcutaneous adipose tissue amount ( J:156376 )
• decrease in the weight of subcutaneous WAT relative to total body weight compared to wild-type controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory