About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Drd2-cre)ER44Gsat
transgene insertion ER44, GENSAT Project at Rockefeller University
MGI:3836635
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Ehmt2tm1.1Tara/Ehmt2tm1.1Tara
Tg(Drd2-cre)ER44Gsat/0
involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:4418569
cn2
Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Drd2-cre)ER44Gsat/0
involves: C57BL/6 * FVB/N MGI:5515337
cn3
Ppp1r1btm5.1Pggd/Ppp1r1btm5.1Pggd
Tg(Drd2-cre)ER44Gsat/0
Tg(Drd2-EGFP)S118Gsat/0
involves: C57BL/6 * FVB/N * FVB/NTac MGI:4830460


Genotype
MGI:4418569
cn1
Allelic
Composition
Ehmt2tm1.1Tara/Ehmt2tm1.1Tara
Tg(Drd2-cre)ER44Gsat/0
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt2tm1.1Tara mutation (0 available); any Ehmt2 mutation (47 available)
Tg(Drd2-cre)ER44Gsat mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• small significant negative gain in excitability of medium spiny neurons

behavior/neurological
• greater increase in locomotor and exploratory behaviors in response to caffeine, a repressor of Drd2.
• greater increase in locomotor and exploratory behaviors in response by to caffeine, a repressor of Drd2




Genotype
MGI:5515337
cn2
Allelic
Composition
Prkar2btm3Gsm/Prkar2btm2Gsm
Tg(Drd2-cre)ER44Gsat/0
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar2btm2Gsm mutation (1 available); any Prkar2b mutation (2 available)
Prkar2btm3Gsm mutation (0 available); any Prkar2b mutation (2 available)
Tg(Drd2-cre)ER44Gsat mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• hyperactivity phenotype is lost

adipose tissue

growth/size/body
• low body weight
• lean body

homeostasis/metabolism
• low serum leptin levels




Genotype
MGI:4830460
cn3
Allelic
Composition
Ppp1r1btm5.1Pggd/Ppp1r1btm5.1Pggd
Tg(Drd2-cre)ER44Gsat/0
Tg(Drd2-EGFP)S118Gsat/0
Genetic
Background
involves: C57BL/6 * FVB/N * FVB/NTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r1btm5.1Pggd mutation (0 available); any Ppp1r1b mutation (2 available)
Tg(Drd2-cre)ER44Gsat mutation (2 available)
Tg(Drd2-EGFP)S118Gsat mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• loss of expression in striatopallidal and striatonigral neurons results in a reduced LTP at the corticostriatal synapses

behavior/neurological
• haloperidol-induced catalepsy is strongly reduced
• in an open-field test





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
10/15/2019
MGI 6.14
The Jackson Laboratory