All Phenotypes Tg(Drd2-cre)ER44Gsat MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Drd2-cre)ER44Gsat
transgene insertion ER44, GENSAT Project at Rockefeller University
MGI:3836635

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ehmt2^tm1.1Tara/Ehmt2^tm1.1Tara Tg(Drd2-cre)ER44Gsat/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:4418569
cn2	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Drd2-cre)ER44Gsat/0	involves: C57BL/6 * FVB/N	MGI:5515337
cn3	Ppp1r1b^tm5.1Pggd/Ppp1r1b^tm5.1Pggd Tg(Drd2-cre)ER44Gsat/0 Tg(Drd2-EGFP)S118Gsat/0	involves: C57BL/6 * FVB/N * FVB/NTac	MGI:4830460

Allelic Composition	Ehmt2^tm1.1Tara/Ehmt2^tm1.1Tara Tg(Drd2-cre)ER44Gsat/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ehmt2^tm1.1Tara mutation (0 available); any Ehmt2 mutation (55 available)
Tg(Drd2-cre)ER44Gsat mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neuron physiology ( J:155739 )

• small significant negative gain in excitability of medium spiny neurons

behavior/neurological

enhanced behavioral response to xenobiotic ( J:155739 )

• greater increase in locomotor and exploratory behaviors in response to caffeine, a repressor of Drd2.

induced hyperactivity ( J:155739 )

• greater increase in locomotor and exploratory behaviors in response by to caffeine, a repressor of Drd2

Allelic Composition	Prkar2b^tm3Gsm/Prkar2b^tm2Gsm Tg(Drd2-cre)ER44Gsat/0
Genetic Background	involves: C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prkar2b^tm2Gsm mutation (1 available); any Prkar2b mutation (27 available)
Prkar2b^tm3Gsm mutation (0 available); any Prkar2b mutation (27 available)
Tg(Drd2-cre)ER44Gsat mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:196157 )

N	• hyperactivity phenotype is lost

adipose tissue

decreased total body fat amount ( J:196157 )

• low adiposity

growth/size/body

decreased body weight ( J:196157 )

• low body weight

• lean body

homeostasis/metabolism

decreased circulating leptin level ( J:196157 )

• low serum leptin levels

Allelic Composition	Ppp1r1b^tm5.1Pggd/Ppp1r1b^tm5.1Pggd Tg(Drd2-cre)ER44Gsat/0 Tg(Drd2-EGFP)S118Gsat/0
Genetic Background	involves: C57BL/6 * FVB/N * FVB/NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r1b^tm5.1Pggd mutation (0 available); any Ppp1r1b mutation (18 available)
Tg(Drd2-cre)ER44Gsat mutation (2 available)
Tg(Drd2-EGFP)S118Gsat mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

reduced long-term potentiation ( J:163700 )

• loss of expression in striatopallidal and striatonigral neurons results in a reduced LTP at the corticostriatal synapses

behavior/neurological

enhanced behavioral response to cocaine ( J:163700 )

impaired behavioral response to xenobiotic ( J:163700 )

• haloperidol-induced catalepsy is strongly reduced

hyperactivity ( J:163700 )

• in an open-field test

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