All Phenotypes Igh<tm3Mnz> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Igh^tm3Mnz
targeted mutation 3, Michel C Nussenzweig
MGI:3836312

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Igh^tm3Mnz/Igh^tm4.1Mnz	involves: C57BL/6	MGI:4452375
cn2	Aicda^tm1Hon/Aicda^tm1Hon Igh^tm3Mnz/Igh^tm4.1Mnz Trp53bp1^tm1Jc/Trp53bp1^tm1Jc	involves: 129 * C57BL/6 * CBA	MGI:4452376
cn3	Aicda^tm1(cre)Mnz/Aicda⁺ Igh^tm3Mnz/Igh⁺ Myc^tm39Mnz/Myc⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3836396
cn4	Aicda^tm1(cre)Mnz/Aicda⁺ Igh^tm3Mnz/Igh⁺ Myc^tm37Mnz/Myc⁺	involves: 129P2/OlaHsd * C57BL/6	MGI:3836397
cx5	Aicda^tm1Hon/Aicda^tm1Hon Igh^tm3Mnz/Igh⁺ Myc^tm37Mnz/Myc⁺	involves: C57BL/6 * CBA	MGI:3836398

Allelic Composition	Igh^tm3Mnz/Igh^tm4.1Mnz
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igh^tm3Mnz mutation (1 available); any Igh mutation (43 available)
Igh^tm4.1Mnz mutation (0 available); any Igh mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:159173 )

N	• mice exhibit normal B cell development and class switch recombination to IgG1 following stimulation with LPS and IL4

Allelic Composition	Aicda^tm1Hon/Aicda^tm1Hon Igh^tm3Mnz/Igh^tm4.1Mnz Trp53bp1^tm1Jc/Trp53bp1^tm1Jc
Genetic Background	involves: 129 * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicda^tm1Hon mutation (7 available); any Aicda mutation (55 available)
Igh^tm3Mnz mutation (1 available); any Igh mutation (43 available)
Igh^tm4.1Mnz mutation (0 available); any Igh mutation (43 available)
Trp53bp1^tm1Jc mutation (1 available); any Trp53bp1 mutation (100 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal class switch recombination ( J:159173 )

• I-SceI mediated class switch recombination in LPS- and IL4-stimulated B cells is decreased compared to similarly treated Aicda^tm1Hon/Aicda^tm1Hon Igh^tm3Mnz/Igh^tm4.1Mnz B cells

immune system

abnormal class switch recombination ( J:159173 )

• I-SceI mediated class switch recombination in LPS- and IL4-stimulated B cells is decreased compared to similarly treated Aicda^tm1Hon/Aicda^tm1Hon Igh^tm3Mnz/Igh^tm4.1Mnz B cells

Allelic Composition	Aicda^tm1(cre)Mnz/Aicda⁺ Igh^tm3Mnz/Igh⁺ Myc^tm39Mnz/Myc⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicda^tm1(cre)Mnz mutation (1 available); any Aicda mutation (55 available)
Igh^tm3Mnz mutation (1 available); any Igh mutation (43 available)
Myc^tm39Mnz mutation (1 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

spontaneous chromosome breakage ( J:145691 )

• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15

• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

immune system

abnormal B cell physiology ( J:145691 )

• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15

• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

hematopoietic system

abnormal B cell physiology ( J:145691 )

• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15

• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

Allelic Composition	Aicda^tm1(cre)Mnz/Aicda⁺ Igh^tm3Mnz/Igh⁺ Myc^tm37Mnz/Myc⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicda^tm1(cre)Mnz mutation (1 available); any Aicda mutation (55 available)
Igh^tm3Mnz mutation (1 available); any Igh mutation (43 available)
Myc^tm37Mnz mutation (1 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

spontaneous chromosome breakage ( J:145691 )

• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15

• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

immune system

abnormal B cell physiology ( J:145691 )

• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15

• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

hematopoietic system

abnormal B cell physiology ( J:145691 )

• B cells within in Peyer's Patches or splenic B cells stimulated in vitro can have chromosomal translocations involving chromosomes 12 and 15

• the chromosome fusions occur precisely at the two loxP sites that exist in the Igh and Myc mutant alleles

Allelic Composition	Aicda^tm1Hon/Aicda^tm1Hon Igh^tm3Mnz/Igh⁺ Myc^tm37Mnz/Myc⁺
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicda^tm1Hon mutation (7 available); any Aicda mutation (55 available)
Igh^tm3Mnz mutation (1 available); any Igh mutation (43 available)
Myc^tm37Mnz mutation (1 available); any Myc mutation (42 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

induced chromosome breakage ( J:145691 )

• activated B cells transfected with yeast-derived I-SceI endonuclease have a high incidence of chromosomal translocations involving chromosomes 12 and 15

• chromosome fusions occur within 2.2 kb of the I-SceI recognition sites that are present in the Myc and Igh mutant alleles

• out of 21 translocation junctions, 19 involved 1-7 bps of microhomology (average microhomology of 2.9 bps) and two included insertions

• translocation rates are similar when B cells are transfected with Aicda, cre, or SceI genes

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