Mouse Genome Informatics
cx1
    Tg(MMTV-AURKA)#Cxd/?
Trp53tm1Tyj/Trp53+

involves: 129S2/SvPas * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• mammary tumors start to develop at 6 months of age
• 70% of mice have developed tumors by 18 months of age

cellular
• 25% of mammary epithelial cells from 4-month old mice are polyploidy and show premature chromatid segregation
• about half of mammary epithelial tumor cells are polyploidy

endocrine/exocrine glands
• parous mice over one year in age have more extensive ductal branching than transgenic mice not carrying a mutant Trp53 allele (J:145680)
• parous mice have almost 6-fold more actively proliferating cells in the mammary epithelium than in controls (J:145680)
• 10% of mammary epithelial cells from 4-month old mice contain more than 2 centrosomes per nucleus compared to about 1% mammary epithelial cells from control mice (J:145680)

integument
• parous mice over one year in age have more extensive ductal branching than transgenic mice not carrying a mutant Trp53 allele (J:145680)
• parous mice have almost 6-fold more actively proliferating cells in the mammary epithelium than in controls (J:145680)
• 10% of mammary epithelial cells from 4-month old mice contain more than 2 centrosomes per nucleus compared to about 1% mammary epithelial cells from control mice (J:145680)

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:145680


Mouse Genome Informatics
tg2
    Tg(MMTV-AURKA)#Cxd/?
involves: FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• mice that have given birth at least 5 times have increased risk of developing mammary tumors
• tumors first become visible at 9 months of age
• about 40% of mice develop mammary tumors consisting of adenocarcinomas or spindle cell carcinoma
• in contrast only about 8% of virgin mice develop mammary tumors over a two-year time frame
• is noted in about 3% of mice that have given birth at least 5 times (J:145680)
• kidney tumor is observed in about 3% of mice that have given birth at least 5 times

cellular
• 25% of mammary epithelial cells from 4-month old mice are polyploidy and show premature chromatid segregation
• about half of mammary epithelial tumor cells are polyploidy

endocrine/exocrine glands
• parous mice over one year in age have more extensive ductal branching (J:145680)
• mammary glands are visibly larger at 4 month of age (J:145680)
• 10% of mammary epithelial cells from 4-month old mice contain more than 2 centrosomes per nucleus compared to about 1% mammary epithelial cells from control mice (J:145680)
• parous mice over one year in age have increased alveolization within the gland (J:145680)
• mammary epithelium at 2 months of age exhibit multiple layers of cells in contrast to the one or two cell layers found in control mice (J:145680)
• parous mice have 4-fold more actively proliferating cells in the mammary epithelium than controls (J:145680)

reproductive system
• is observed in mice that have given birth multiple times (J:145680)

integument
• parous mice over one year in age have more extensive ductal branching (J:145680)
• mammary glands are visibly larger at 4 month of age (J:145680)
• 10% of mammary epithelial cells from 4-month old mice contain more than 2 centrosomes per nucleus compared to about 1% mammary epithelial cells from control mice (J:145680)
• parous mice over one year in age have increased alveolization within the gland (J:145680)
• mammary epithelium at 2 months of age exhibit multiple layers of cells in contrast to the one or two cell layers found in control mice (J:145680)
• parous mice have 4-fold more actively proliferating cells in the mammary epithelium than controls (J:145680)

Mouse Models of Human Disease
OMIM IDRef(s)
Breast Cancer 114480 J:145680