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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Scgb1a1-rtTA,-tTS,tetO-TGFB1*)1Eli
transgene insertion 1, Jack A Elias
MGI:3836057
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Egr1tm1Jmi/Egr1tm1Jmi
Tg(Scgb1a1-rtTA,-tTS,tetO-TGFB1*)1Eli/? 		involves: 129 * C57BL/6 MGI:4821398
tg2
 		Tg(Scgb1a1-rtTA,-tTS,tetO-TGFB1*)1Eli/0 involves: C57BL/6 MGI:4821392


Genotype
MGI:4821398
cx1
Allelic
Composition		 Egr1tm1Jmi/Egr1tm1Jmi
Tg(Scgb1a1-rtTA,-tTS,tetO-TGFB1*)1Eli/?
Genetic
Background		 involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr1tm1Jmi mutation (1 available); any Egr1 mutation (19 available)
Tg(Scgb1a1-rtTA,-tTS,tetO-TGFB1*)1Eli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:92469 )
N
• early apoptosis is not observed
lung inflammation ( J:92469 )
• inflammation occurs but with moderately reduced inflammatory cell accumulation relative to controls carrying only the transgene
abnormal pulmonary alveolus morphology ( J:92469 )
• alveolar remodeling is diminished
pulmonary fibrosis ( J:92469 )
• fibrosis response is reduced

immune system
lung inflammation ( J:92469 )
• inflammation occurs but with moderately reduced inflammatory cell accumulation relative to controls carrying only the transgene




Genotype
MGI:4821392
tg2
Allelic
Composition		 Tg(Scgb1a1-rtTA,-tTS,tetO-TGFB1*)1Eli/0
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
lung inflammation ( J:92469 )
• inflammatory response evident in lungs after 2 days of dox treatment and increases for 10 days
• increased myocytes and myofibroblasts by 10 days of dox treatment
abnormal lung epithelium morphology ( J:92469 )
• apoptosis is increased 12 hours after dox induction
• apoptosis peaks at 48 hours and then disappears
pulmonary fibrosis ( J:92469 )
• airway and parenchymal fibrotic response by 2 days after dox treatment
• fibrotic response of alveolar perenchyma develops later
• lung collagen content is increased after 2 months of dox treatment

immune system
lung inflammation ( J:92469 )
• inflammatory response evident in lungs after 2 days of dox treatment and increases for 10 days
• increased myocytes and myofibroblasts by 10 days of dox treatment




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory