All Phenotypes Cldn6<tm1(cre)Dkwu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cldn6^tm1(cre)Dkwu
targeted mutation 1, Doris Wu
MGI:3834897

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cldn6^tm1(cre)Dkwu/Cldn6^tm1(cre)Dkwu	C57BL/6-Cldn6^tm1(cre)Dkwu	MGI:3844724
cn2	Atp7a^tm1.1Mjp/Y Cldn6^tm1(cre)Dkwu/Cldn6⁺	involves: C57BL/6	MGI:5447642
cn3	Atp7a^tm1.1Mjp/Atp7a⁺ Cldn6^tm1(cre)Dkwu/Cldn6⁺	involves: C57BL/6	MGI:5447643

Allelic Composition	Cldn6^tm1(cre)Dkwu/Cldn6^tm1(cre)Dkwu
Genetic Background	C57BL/6-Cldn6^tm1(cre)Dkwu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cldn6^tm1(cre)Dkwu mutation (1 available); any Cldn6 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:145443 )

• mice are viable, fertile, and show no gross morphological or behavioral abnormalities

Allelic Composition	Atp7a^tm1.1Mjp/Y Cldn6^tm1(cre)Dkwu/Cldn6⁺
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atp7a^tm1.1Mjp mutation (0 available); any Atp7a mutation (69 available)
Cldn6^tm1(cre)Dkwu mutation (1 available); any Cldn6 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Developmental and vascular abnormalities in Atp7a^tm1.1Mjp/Y Cldn6^tm1(cre)Dkwu/Cldn6⁺ males

mortality/aging

prenatal lethality, complete penetrance ( J:189931 )

• no mice are born

embryo

decreased embryo size ( J:189931 )

• at E10.5

abnormal tail bud morphology ( J:189931 )

• abnormal orientation at E10.5

pale yolk sac ( J:189931 )

craniofacial

abnormal frontonasal prominence morphology ( J:189931 )

• at E10.5

growth/size/body

decreased embryo size ( J:189931 )

• at E10.5

integument

pallor ( J:189931 )

• embryos lack blood-filled vascular network

limbs/digits/tail

abnormal tail bud morphology ( J:189931 )

• abnormal orientation at E10.5

Allelic Composition	Atp7a^tm1.1Mjp/Atp7a⁺ Cldn6^tm1(cre)Dkwu/Cldn6⁺
Genetic Background	involves: C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Patches of hypopigmentation in coats of Atp7a^tm1.1Mjp/Atp7a⁺ Cldn6^tm1(cre)Dkwu/Cldn6⁺ females

mortality/aging

postnatal lethality, incomplete penetrance ( J:189931 )

• only two mice survive beyond the second day after birth

prenatal lethality, incomplete penetrance ( J:189931 )

• fewer than expected mice are born

integument

curly vibrissae ( J:189931 )

pigmentation

hypopigmentation ( J:189931 )

• mosaic pattern of hypopigmented coat coloring in surviving mice

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