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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Bag3tm1.1Jhl
targeted mutation 1.1, Jeong-Hwa Lee
MGI:3831334
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Bag3tm1.1Jhl/Bag3tm1.1Jhl B6.129S2-Bag3tm1.1Jhl MGI:3831337


Genotype
MGI:3831337
hm1
Allelic
Composition
Bag3tm1.1Jhl/Bag3tm1.1Jhl
Genetic
Background
B6.129S2-Bag3tm1.1Jhl
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bag3tm1.1Jhl mutation (0 available); any Bag3 mutation (31 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice are born at the expected Mendelian ratio but die before three weeks of age

growth/size/body
• starting at 7 days of age, mice fail to gain as much weight as controls
• mice start losing weight at 12 days of age, which continues until their death

adipose tissue
• there is a severe reduction in the amount of subcutaneous fat found at 16 days of age
• the perigonadal fat pad is severely reduced in size at 16 days of age

homeostasis/metabolism
• glucose levels are one-third of that in controls at 16 days of age
• insulin levels are about one-third of that in controls at 16 days of age
• levels of beta-hydroxybutyrate are 2.5 fold higher than that found in controls at 16 days of age
• circulating cholesterol levels are 60% of that found in controls at 16 days of age
• circulating triglyceride levels are only 26% of that found in controls at 16 days of age

liver/biliary system
• relative liver weight is only 80% that of controls at 16 days of age
• the liver contains increased numbers of lipid particles that are also enlarged
• free fatty acid levels in the liver are increased two-fold, triglyceride levels 2.8 fold, and cholesterol levels 3.4 fold
• the liver appears pale at 16 days of age

immune system
• involution of the thymus occurs after two weeks of age
• thymus weight per total body weight is normal at 14 days of age but is only 51% of wild-type at 16 days of age
• thymus cellularity is one-fifth that of wild-type controls after 15 days of age
• leukocyte numbers are decreased by more than half at 16 days of age compared to controls
• neutrophil numbers are decreased by more than half at 16 days of age though their relative proportion to other leukocytes is normal
• lymphocyte numbers are decreased by more than half at 16 days of age though their relative proportion to other leukocytes is normal
• involution of the spleen occurs in the first few weeks of life
• spleen weight per total body weight is normal at 12 days of age, is only 50% of wild-type controls at 14 days of age, and is 36% of wild-type at 16 days of age
• spleen cellularity is one-tenth that of wild-type controls after 15 days of age

hematopoietic system
• involution of the thymus occurs after two weeks of age
• thymus weight per total body weight is normal at 14 days of age but is only 51% of wild-type at 16 days of age
• thymus cellularity is one-fifth that of wild-type controls after 15 days of age
• leukocyte numbers are decreased by more than half at 16 days of age compared to controls
• neutrophil numbers are decreased by more than half at 16 days of age though their relative proportion to other leukocytes is normal
• lymphocyte numbers are decreased by more than half at 16 days of age though their relative proportion to other leukocytes is normal
• involution of the spleen occurs in the first few weeks of life
• spleen weight per total body weight is normal at 12 days of age, is only 50% of wild-type controls at 14 days of age, and is 36% of wild-type at 16 days of age
• spleen cellularity is one-tenth that of wild-type controls after 15 days of age

integument
• there is a severe reduction in the amount of subcutaneous fat found at 16 days of age

endocrine/exocrine glands
• involution of the thymus occurs after two weeks of age
• thymus weight per total body weight is normal at 14 days of age but is only 51% of wild-type at 16 days of age
• thymus cellularity is one-fifth that of wild-type controls after 15 days of age





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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory