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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(Pbsn-IGF1*)5305Ng
transgene insertion 5305, Norman M Greenberg
MGI:3831172
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(Pbsn-IGF1*)5305Ng/0
Tg(TRAMP)8247Ng/0
involves: C57BL/6 * FVB/N MGI:3831310
tg2
Tg(Pbsn-IGF1*)5305Ng/0 involves: FVB/N MGI:3831312


Genotype
MGI:3831310
cx1
Allelic
Composition
Tg(Pbsn-IGF1*)5305Ng/0
Tg(TRAMP)8247Ng/0
Genetic
Background
involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pbsn-IGF1*)5305Ng mutation (1 available)
Tg(TRAMP)8247Ng mutation (2 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
endocrine/exocrine glands

reproductive system

neoplasm
• by 24 weeks, mice show metastatic deposits in pelvic lymph nodes, renal lymph nodes, lungs, salivary glands and liver while TRAMP littermates primarily show deposits in the pelvic lymph nodes
• fewer multi-lobe tumors develop at 18 and 24 weeks (14 and 57% respectively) than in hemizygous TRAMP littermates (45 and 86%, respectively)

Mouse Models of Human Disease
OMIM ID Ref(s)
Prostate Cancer 176807 J:144539




Genotype
MGI:3831312
tg2
Allelic
Composition
Tg(Pbsn-IGF1*)5305Ng/0
Genetic
Background
involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Pbsn-IGF1*)5305Ng mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• prostate remains tumor-free for 1 year
• observed abnormalities are consistent with prostatic intraepithelial neoplasia (PIN)

endocrine/exocrine glands
• transgenic mice have increased numbers of abnormal acini, specifically in the lateral lobe of the prostate, compared to controls
• prostate sections routinely demonstrate disorganized epithelial cells, epithelial stratifications, areas of epithelial tufting with teardrop shaped cells having elongated nuclei, nuclear atypia and heterochromatic nuclei
• observed abnormalities are consistent with prostatic intraepithelial neoplasia (PIN)
• observed abnormalities are consistent with prostatic intraepithelial neoplasia (PIN)

reproductive system
• transgenic mice have increased numbers of abnormal acini, specifically in the lateral lobe of the prostate, compared to controls
• prostate sections routinely demonstrate disorganized epithelial cells, epithelial stratifications, areas of epithelial tufting with teardrop shaped cells having elongated nuclei, nuclear atypia and heterochromatic nuclei
• observed abnormalities are consistent with prostatic intraepithelial neoplasia (PIN)
• observed abnormalities are consistent with prostatic intraepithelial neoplasia (PIN)





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory