Mouse Genome Informatics
cx1
    Tg(Pbsn-IGF1*)5305Ng/0
Tg(TRAMP)8247Ng/0

involves: C57BL/6 * FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
• by 24 weeks, mice show metastatic deposits in pelvic lymph nodes, renal lymph nodes, lungs, salivary glands and liver while TRAMP littermates primarily show deposits in the pelvic lymph nodes (J:144539)
• fewer multi-lobe tumors develop at 18 and 24 weeks (14 and 57% respectively) than in hemizygous TRAMP littermates (45 and 86%, respectively) (J:144539)

Mouse Models of Human Disease
OMIM IDRef(s)
Prostate Cancer 176807 J:144539


Mouse Genome Informatics
tg2
    Tg(Pbsn-IGF1*)5305Ng/0
involves: FVB/N
Key:
phenotype observed in females WTSI Wellcome Trust Sanger Institute
phenotype observed in males EuPh Europhenome
N normal phenotype
tumorigenesis
N
• prostate remains tumor-free for 1 year (J:144539)
• observed abnormalities are consistent with prostatic intraepithelial neoplasia (PIN) (J:144539)

endocrine/exocrine glands
• transgenic mice have increased numbers of abnormal acini, specifically in the lateral lobe of the prostate, compared to controls (J:144539)
• prostate sections routinely demonstrate disorganized epithelial cells, epithelial stratifications, areas of epithelial tufting with teardrop shaped cells having elongated nuclei, nuclear atypia and heterochromatic nuclei (J:144539)
• observed abnormalities are consistent with prostatic intraepithelial neoplasia (PIN) (J:144539)

reproductive system
• transgenic mice have increased numbers of abnormal acini, specifically in the lateral lobe of the prostate, compared to controls (J:144539)
• prostate sections routinely demonstrate disorganized epithelial cells, epithelial stratifications, areas of epithelial tufting with teardrop shaped cells having elongated nuclei, nuclear atypia and heterochromatic nuclei (J:144539)
• observed abnormalities are consistent with prostatic intraepithelial neoplasia (PIN) (J:144539)