Phenotypes associated with this allele

• Allele Symbol: Tg(Pbsn-IGF1*)5305Ng
• Allele Name: transgene insertion 5305, Norman M Greenberg
• Allele ID: MGI:3831172
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Tg(Pbsn-IGF1*)5305Ng/0 Tg(TRAMP)8247Ng/0	involves: C57BL/6 * FVB/N	MGI:3831310
tg2	Tg(Pbsn-IGF1*)5305Ng/0	involves: FVB/N	MGI:3831312

Genotype
MGI:3831310

cx1

• Allelic Composition: Tg(Pbsn-IGF1*)5305Ng/0; Tg(TRAMP)8247Ng/0
• Genetic Background: involves: C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased prostate gland tumor incidence ( J:144539 )

♂

abnormal metastatic potential ( J:144539 )

♂ • by 24 weeks, mice show metastatic deposits in pelvic lymph nodes, renal lymph nodes, lungs, salivary glands and liver while TRAMP littermates primarily show deposits in the pelvic lymph nodes

decreased tumor incidence ( J:144539 )

♂ • fewer multi-lobe tumors develop at 18 and 24 weeks (14 and 57% respectively) than in hemizygous TRAMP littermates (45 and 86%, respectively)

endocrine/exocrine glands

increased prostate gland tumor incidence ( J:144539 )

♂

reproductive system

increased prostate gland tumor incidence ( J:144539 )

♂

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
prostate cancer		DOID:10283	OMIM:176807 OMIM:300147 OMIM:300704 OMIM:601518 OMIM:602759 OMIM:608656 OMIM:608658 OMIM:609299 OMIM:609558 OMIM:610321 OMIM:610997 OMIM:611100 OMIM:611868 OMIM:611928 OMIM:611955 OMIM:611958 OMIM:611959	J:144539

Genotype
MGI:3831312

tg2

• Allelic Composition: Tg(Pbsn-IGF1*)5305Ng/0
• Genetic Background: involves: FVB/N

neoplasm

neoplasm ( J:144539 )

N • prostate remains tumor-free for 1 year

increased prostate intraepithelial neoplasia incidence ( J:144539 )

♂ • observed abnormalities are consistent with prostatic intraepithelial neoplasia (PIN)

endocrine/exocrine glands

abnormal prostate gland morphology ( J:144539 )

♂ • transgenic mice have increased numbers of abnormal acini, specifically in the lateral lobe of the prostate, compared to controls

abnormal prostate gland epithelium morphology ( J:144539 )

♂ • prostate sections routinely demonstrate disorganized epithelial cells, epithelial stratifications, areas of epithelial tufting with teardrop shaped cells having elongated nuclei, nuclear atypia and heterochromatic nuclei

♂ • observed abnormalities are consistent with prostatic intraepithelial neoplasia (PIN)

increased prostate intraepithelial neoplasia incidence ( J:144539 )

♂ • observed abnormalities are consistent with prostatic intraepithelial neoplasia (PIN)

reproductive system

abnormal prostate gland morphology ( J:144539 )

♂ • transgenic mice have increased numbers of abnormal acini, specifically in the lateral lobe of the prostate, compared to controls

abnormal prostate gland epithelium morphology ( J:144539 )

♂ • prostate sections routinely demonstrate disorganized epithelial cells, epithelial stratifications, areas of epithelial tufting with teardrop shaped cells having elongated nuclei, nuclear atypia and heterochromatic nuclei

♂ • observed abnormalities are consistent with prostatic intraepithelial neoplasia (PIN)

increased prostate intraepithelial neoplasia incidence ( J:144539 )

♂ • observed abnormalities are consistent with prostatic intraepithelial neoplasia (PIN)