Analysis Tools
immune system
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• homing of lymphocytes into the gut is suppressed compared to in wild-type mice
• in a DSS-induced model of colitis, homing of lymphocytes is reduced 50% compared to in similarly treated wild-type mice
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• CXCL12-stimulated lymphocyte migration in the presence of transmigration inserts coated in VCAM1 or MAdCAM1 is reduced 50%, and exhibit reduced lateral migration compared to the migration of similarly treated wild-type cells
• 50% fewer lymphocytes exhibit transendothelial migration under shear stress conditions of 2.0 dyne/cm2 compared to similarly treated wild-type cells
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• in cation conditions, the basal adhesiveness of lymphocytes is increased compared to in wild-type cells
• despite normal rolling behavior, lymphocytes exhibit increased firm adhesion to Peyer patch venules compared to wild-type cells
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• fewer mononuclear cells are present in the intraepithelial lymphocyte compartment and the Peyer's patches compared to in wild-type mice
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• mice exhibit a reduction in the number of lymphocytes in the gut (ei. Peyer's patches and intraepithelial lymphocyte compartments)
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• fewer B220+ B cells are present in the intraepithelial lymphocyte compartment and the Peyer's patches compared to in wild-type mice
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• fewer CD3+ T cells are present in the intraepithelial lymphocyte compartment and the Peyer's patches compared to in wild-type mice
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hematopoietic system
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• homing of lymphocytes into the gut is suppressed compared to in wild-type mice
• in a DSS-induced model of colitis, homing of lymphocytes is reduced 50% compared to in similarly treated wild-type mice
|
|
• CXCL12-stimulated lymphocyte migration in the presence of transmigration inserts coated in VCAM1 or MAdCAM1 is reduced 50%, and exhibit reduced lateral migration compared to the migration of similarly treated wild-type cells
• 50% fewer lymphocytes exhibit transendothelial migration under shear stress conditions of 2.0 dyne/cm2 compared to similarly treated wild-type cells
|
|
• in cation conditions, the basal adhesiveness of lymphocytes is increased compared to in wild-type cells
• despite normal rolling behavior, lymphocytes exhibit increased firm adhesion to Peyer patch venules compared to wild-type cells
|
|
• fewer mononuclear cells are present in the intraepithelial lymphocyte compartment and the Peyer's patches compared to in wild-type mice
|
|
• mice exhibit a reduction in the number of lymphocytes in the gut (ei. Peyer's patches and intraepithelial lymphocyte compartments)
|
|
• fewer B220+ B cells are present in the intraepithelial lymphocyte compartment and the Peyer's patches compared to in wild-type mice
|
|
• fewer CD3+ T cells are present in the intraepithelial lymphocyte compartment and the Peyer's patches compared to in wild-type mice
|
cellular
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• homing of lymphocytes into the gut is suppressed compared to in wild-type mice
• in a DSS-induced model of colitis, homing of lymphocytes is reduced 50% compared to in similarly treated wild-type mice
|
|
• CXCL12-stimulated lymphocyte migration in the presence of transmigration inserts coated in VCAM1 or MAdCAM1 is reduced 50%, and exhibit reduced lateral migration compared to the migration of similarly treated wild-type cells
• 50% fewer lymphocytes exhibit transendothelial migration under shear stress conditions of 2.0 dyne/cm2 compared to similarly treated wild-type cells
|
|
• in cation conditions, the basal adhesiveness of lymphocytes is increased compared to in wild-type cells
• despite normal rolling behavior, lymphocytes exhibit increased firm adhesion to Peyer patch venules compared to wild-type cells
|
