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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Glp2rtm1Ddr
targeted mutation 1, D J Drucker
MGI:3827107
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Glp2rtm1Ddr/Glp2rtm1Ddr involves: C57BL/6 MGI:5319216
cx2
 		ApcMin/Apc+
Glp2rtm1Ddr/Glp2r+ 		involves: C57BL/6J MGI:3827117
cx3
 		ApcMin/Apc+
Glp2rtm1Ddr/Glp2rtm1Ddr 		involves: C57BL/6J MGI:3827123


Genotype
MGI:5319216
hm1
Allelic
Composition		 Glp2rtm1Ddr/Glp2rtm1Ddr
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Glp2rtm1Ddr mutation (0 available); any Glp2r mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
increased susceptibility to xenobiotic induced morbidity/mortality ( J:182545 )
• increase in the proportion of moribund mice following indomethacin induced small bowel enteritis

digestive/alimentary system
digestive/alimentary phenotype ( J:182545 )
N
• intestinal morphology is similar to wild-type controls in nonstressed mice and in mice treated with dextran sulfate
abnormal digestive system physiology ( J:182545 )
• sustained h[Gly2]-GLP-2 (glucagon like peptide 2) administration fails to elicit an intestinotrophic response unlike in wild-type controls
abnormal feces composition ( J:182545 )
• significant reductions in the proportions of Firmicutes and Actinobacteria and a significant increase in Bacteroidetes and Clostridiales in the feces
abnormal intestine physiology ( J:182545 )
• increase in small intestinal sensitivity to indomethacin or irinotecan toxicity
• increased small bowel bacterial load
abnormal Paneth cell physiology ( J:182545 )
• expression analysis indicates defects in Paneth cell regulated host-bacteria interactions and cultured Paneth cells show reduced bactericidal activity after stimulation with carbamylcholine and LPS

homeostasis/metabolism
increased susceptibility to xenobiotic induced morbidity/mortality ( J:182545 )
• increase in the proportion of moribund mice following indomethacin induced small bowel enteritis
increased physiological sensitivity to xenobiotic ( J:182545 )
• more mice show signs of bacterial infection after indomethacin treatment
• irinotecan treatment induces a significant decrease in jejunal crypt density and depth in contrast to controls where only crypt depth is decreased
• systemic bacteremia is seen after irinotecan treatment




Genotype
MGI:3827117
cx2
Allelic
Composition		 ApcMin/Apc+
Glp2rtm1Ddr/Glp2r+
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (154 available)
Glp2rtm1Ddr mutation (0 available); any Glp2r mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased intestinal adenoma incidence ( J:141821 )
• number similar to situation in ApcMin heterozygous mice
abnormal tumor morphology ( J:141821 )
• size similar to situation in ApcMin heterozygous mice

digestive/alimentary system
abnormal intestinal epithelium morphology ( J:141821 )
• villus height is similar to ApcMin heterozygotes
abnormal crypts of Lieberkuhn morphology ( J:141821 )
• crypt morphology is similar to ApcMin heterozygotes
intestine polyps ( J:141821 )
• number similar to situation in ApcMin heterozygous mice
increased intestinal adenoma incidence ( J:141821 )
• number similar to situation in ApcMin heterozygous mice

endocrine/exocrine glands
abnormal crypts of Lieberkuhn morphology ( J:141821 )
• crypt morphology is similar to ApcMin heterozygotes




Genotype
MGI:3827123
cx3
Allelic
Composition		 ApcMin/Apc+
Glp2rtm1Ddr/Glp2rtm1Ddr
Genetic
Background		 involves: C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (154 available)
Glp2rtm1Ddr mutation (0 available); any Glp2r mutation (39 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal intestinal epithelium morphology ( J:141821 )
• villus height is similar to ApcMin heterozygotes
abnormal crypts of Lieberkuhn morphology ( J:141821 )
• crypt morphology is similar to ApcMin heterozygotes
intestine polyps ( J:141821 )
• number similar to situation in ApcMin heterozygous mice
increased intestinal adenoma incidence ( J:141821 )
• number similar to situation in ApcMin heterozygous mice

endocrine/exocrine glands
abnormal crypts of Lieberkuhn morphology ( J:141821 )
• crypt morphology is similar to ApcMin heterozygotes

neoplasm
increased intestinal adenoma incidence ( J:141821 )
• number similar to situation in ApcMin heterozygous mice
abnormal tumor morphology ( J:141821 )
• size similar to situation in ApcMin heterozygous mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory