Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdhgtm2Xzw mutation
(1 available);
any
Pcdhg mutation
(12 available)
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nervous system
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• brain injections of rAAV8 virus expressing cre
• 6 fold increase in overlaps of Purkinji Cell dendritic branches
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vision/eye
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N |
• mice exhibit normal inner nuclear, inner plexiform and ganglion cell layer thickness and numbers of bipolar cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdhgtm2Xzw mutation
(1 available);
any
Pcdhg mutation
(12 available)
Tg(Chx10-EGFP/cre,-ALPP)2Clc mutation
(1 available)
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vision/eye
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• retinal apoptosis during the first two weeks after birth is increased compared to in wild-type mice
• increased apoptosis is observed in the neuroblast and ganglion cell layers at P0 and is confined to the inner nuclear layer at P7
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• by P14, 40% thinner than in wild-type mice
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• by P14, 40% thinner than in wild-type mice
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• retinal ganglion cells fire at a lower rate in response to flicker stimuli and the time course of the light response is lower than in wild-type mice
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cellular
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• retinal apoptosis during the first two weeks after birth is increased compared to in wild-type mice
• increased apoptosis is observed in the neuroblast and ganglion cell layers at P0 and is confined to the inner nuclear layer at P7
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nervous system
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• brain injections of rAAV8 virus expressing cre
• higher level of dendritic branch overlap than for either mutant allele alone
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behavior/neurological
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N |
• no performance abnormalities in a dowel rod test
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdhgtm2Xzw mutation
(1 available);
any
Pcdhg mutation
(12 available)
Tg(Pax6-cre,GFP)2Pgr mutation
(1 available)
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vision/eye
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N |
• despite the reduction in several retinal cell types, the numbers of horizontal cells, photoreceptors and synapses in the inner plexiform layer are normal
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• the numbers of Muller glial cells is decreased 20% compared to in wild-type mice
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• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice
• the number of Pax6-amacrine cells in the central retina is reduced 58% compared to in wild-type mice
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• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice
• mice exhibit a 15% loss of Pou4f1+ retinal ganglion cells from the central retina compared to in wild-type mice
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• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice
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nervous system
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• the numbers of Muller glial cells is decreased 20% compared to in wild-type mice
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• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice
• the number of Pax6-amacrine cells in the central retina is reduced 58% compared to in wild-type mice
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• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice
• mice exhibit a 15% loss of Pou4f1+ retinal ganglion cells from the central retina compared to in wild-type mice
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• the numbers of bipolar, amacrine and retinal ganglion cells are decreased 45% to 65% compared to in wild-type mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pcdhgem5Rwb mutation
(0 available);
any
Pcdhg mutation
(12 available)
Pcdhgtm2Xzw mutation
(1 available);
any
Pcdhg mutation
(12 available)
Tg(Pax6-cre,GFP)2Pgr mutation
(1 available)
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vision/eye
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• At 14 days of age the inner retina is thinner than normal in both cellular and synaptic layers, but neurite stratification is not disorganized
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nervous system
Analysis Tools
