All Phenotypes Zbtb7b<tm1.2Litt> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Zbtb7b^tm1.2Litt
targeted mutation 1.2, Dan R Littman
MGI:3821621

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Zbtb7b^tm2Litt/Zbtb7b^tm1.2Litt	involves: 129P2/OlaHsd	MGI:3821712
ht2	Zbtb7b^tm1Litt/Zbtb7b^tm1.2Litt	involves: C57BL/6	MGI:3821711
cn3	Zbtb7b^tm2Litt/Zbtb7b^tm1.2Litt Tg(Lck-cre)1Cwi/?	involves: 129P2/OlaHsd * C57BL/6	MGI:3821707
cn4	Cbfb^tm1Itan/Cbfb^tm1Itan Zbtb7b^tm2Litt/Zbtb7b^tm1.2Litt Tg(Lck-cre)1Cwi/0	involves: 129P2/OlaHsd * C57BL/6	MGI:3821709
cx5	B2m^tm1Jae/B2m^tm1Jae Zbtb7b^tm1Litt/Zbtb7b^tm1.2Litt	involves: 129S2/SvPas * C57BL/6	MGI:3821710

Allelic Composition	Zbtb7b^tm2Litt/Zbtb7b^tm1.2Litt
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb7b^tm1.2Litt mutation (1 available); any Zbtb7b mutation (24 available)
Zbtb7b^tm2Litt mutation (2 available); any Zbtb7b mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:141144 )

• there is about a 30-fold reduction in the number of single-positive CD4⁺ cells among mature thymocytes

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:141144 )

• there is about a 30-fold reduction in the number of single-positive CD4⁺ cells among mature thymocytes

Allelic Composition	Zbtb7b^tm1Litt/Zbtb7b^tm1.2Litt
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb7b^tm1.2Litt mutation (1 available); any Zbtb7b mutation (24 available)
Zbtb7b^tm1Litt mutation (0 available); any Zbtb7b mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal double-positive T cell morphology ( J:141144 )

• a double-positive thymocyte population exists that has surface markers of mature single positive thymocytes (HSA^lo-neg TCRbeta^hi) and may represent single-positive CD4⁺ thymoyctes that are redirected to a CD8⁺ T cell lineage

decreased CD4-positive, alpha-beta T cell number ( J:141144 )

• there is about a 2-fold reduction in the number of single-positive CD4⁺ cells among mature thymocytes compared to controls

• there is also a decrease in the number of CD4⁺ T cells in the periphery

increased CD8-positive, alpha-beta T cell number ( J:141144 )

• there is a greater than 20% increase in the number of single-positive CD8⁺ cells among mature thymocytes compared to controls

• there is also an increase in the number of CD8⁺ T cells in the periphery

immune system

abnormal double-positive T cell morphology ( J:141144 )

decreased CD4-positive, alpha-beta T cell number ( J:141144 )

• there is about a 2-fold reduction in the number of single-positive CD4⁺ cells among mature thymocytes compared to controls

• there is also a decrease in the number of CD4⁺ T cells in the periphery

increased CD8-positive, alpha-beta T cell number ( J:141144 )

• there is a greater than 20% increase in the number of single-positive CD8⁺ cells among mature thymocytes compared to controls

• there is also an increase in the number of CD8⁺ T cells in the periphery

increased interferon-gamma secretion ( J:141144 )

• 47% of CD4⁺ T cells produced IFN-gamma after 3 days of stimulation with anti-CD3 and anti-CD28 compared to just 5.6% of wild-type CD4⁺ T cells

Allelic Composition	Zbtb7b^tm2Litt/Zbtb7b^tm1.2Litt Tg(Lck-cre)1Cwi/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)1Cwi mutation (3 available)
Zbtb7b^tm1.2Litt mutation (1 available); any Zbtb7b mutation (24 available)
Zbtb7b^tm2Litt mutation (2 available); any Zbtb7b mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:141144 )

• the number of HSA^hiCD69⁺ and HSA^hi TCRbeta^hi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice

decreased CD4-positive, alpha-beta T cell number ( J:141144 )

• absolute numbers of CD4⁺ single positive mature thymocytes are reduced by 5 to 10 fold compared to controls

• the percentage of CD4⁺ T cells in peripheral lymph nodes is reduced by almost 20-fold

immune system

abnormal T cell differentiation ( J:141144 )

• the number of HSA^hiCD69⁺ and HSA^hi TCRbeta^hi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice

decreased CD4-positive, alpha-beta T cell number ( J:141144 )

• absolute numbers of CD4⁺ single positive mature thymocytes are reduced by 5 to 10 fold compared to controls

• the percentage of CD4⁺ T cells in peripheral lymph nodes is reduced by almost 20-fold

Allelic Composition	Cbfb^tm1Itan/Cbfb^tm1Itan Zbtb7b^tm2Litt/Zbtb7b^tm1.2Litt Tg(Lck-cre)1Cwi/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfb^tm1Itan mutation (1 available); any Cbfb mutation (36 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Zbtb7b^tm1.2Litt mutation (1 available); any Zbtb7b mutation (24 available)
Zbtb7b^tm2Litt mutation (2 available); any Zbtb7b mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell differentiation ( J:141144 )

• the number of HSA^hiCD69⁺ and HSA^hi TCRbeta^hi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice

decreased CD4-positive, alpha-beta T cell number ( J:141144 )

• absolute numbers of CD4⁺ single positive mature thymocytes are reduced between 5-10 fold compared to controls

• however, the percentage of CD4⁺ T cells in peripheral lymph nodes is only slightly reduced

immune system

abnormal T cell differentiation ( J:141144 )

• the number of HSA^hiCD69⁺ and HSA^hi TCRbeta^hi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice

decreased CD4-positive, alpha-beta T cell number ( J:141144 )

• absolute numbers of CD4⁺ single positive mature thymocytes are reduced between 5-10 fold compared to controls

• however, the percentage of CD4⁺ T cells in peripheral lymph nodes is only slightly reduced

Allelic Composition	B2m^tm1Jae/B2m^tm1Jae Zbtb7b^tm1Litt/Zbtb7b^tm1.2Litt
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
B2m^tm1Jae mutation (8 available); any B2m mutation (122 available)
Zbtb7b^tm1.2Litt mutation (1 available); any Zbtb7b mutation (24 available)
Zbtb7b^tm1Litt mutation (0 available); any Zbtb7b mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:141144 )

• single-positive CD8⁺ cells are found among mature thymocytes compared to mice null for just the B2m locus that have no mature CD8⁺ thymocytes

abnormal double-positive T cell morphology ( J:141144 )

• an unusual double-positive thymocyte population exists that has surface markers of mature single positive thymocytes (HSA^lo-neg TCRbeta^hi) and may represent single-positive CD4⁺ thymoyctes that are redirected to a CD8⁺ T cell lineage

hematopoietic system

abnormal CD8-positive, alpha-beta T cell differentiation ( J:141144 )

• single-positive CD8⁺ cells are found among mature thymocytes compared to mice null for just the B2m locus that have no mature CD8⁺ thymocytes

abnormal double-positive T cell morphology ( J:141144 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23