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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Zbtb7btm2Litt
targeted mutation 2, Dan R Littman
MGI:3818473
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Zbtb7btm2Litt/Zbtb7btm2Litt involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:3818476
ht2
 		Zbtb7btm2Litt/Zbtb7btm1.2Litt involves: 129P2/OlaHsd MGI:3821712
cn3
 		Zbtb7btm2Litt/Zbtb7btm1.2Litt
Tg(Lck-cre)1Cwi/? 		involves: 129P2/OlaHsd * C57BL/6 MGI:3821707
cn4
 		Cbfbtm1Itan/Cbfbtm1Itan
Zbtb7btm2Litt/Zbtb7b+
Tg(Lck-cre)1Cwi/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3821708
cn5
 		Cbfbtm1Itan/Cbfbtm1Itan
Zbtb7btm2Litt/Zbtb7btm1.2Litt
Tg(Lck-cre)1Cwi/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3821709


Genotype
MGI:3818476
hm1
Allelic
Composition		 Zbtb7btm2Litt/Zbtb7btm2Litt
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb7btm2Litt mutation (2 available); any Zbtb7b mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
absent CD4-positive, alpha-beta T cells ( J:141519 )
• CD4+ T cells are almost completely absent

immune system
absent CD4-positive, alpha-beta T cells ( J:141519 )
• CD4+ T cells are almost completely absent




Genotype
MGI:3821712
ht2
Allelic
Composition		 Zbtb7btm2Litt/Zbtb7btm1.2Litt
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb7btm1.2Litt mutation (1 available); any Zbtb7b mutation (24 available)
Zbtb7btm2Litt mutation (2 available); any Zbtb7b mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased CD4-positive, alpha-beta T cell number ( J:141144 )
• there is about a 30-fold reduction in the number of single-positive CD4+ cells among mature thymocytes

hematopoietic system
decreased CD4-positive, alpha-beta T cell number ( J:141144 )
• there is about a 30-fold reduction in the number of single-positive CD4+ cells among mature thymocytes




Genotype
MGI:3821707
cn3
Allelic
Composition		 Zbtb7btm2Litt/Zbtb7btm1.2Litt
Tg(Lck-cre)1Cwi/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)1Cwi mutation (3 available)
Zbtb7btm1.2Litt mutation (1 available); any Zbtb7b mutation (24 available)
Zbtb7btm2Litt mutation (2 available); any Zbtb7b mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell differentiation ( J:141144 )
• the number of HSAhiCD69+ and HSAhi TCRbetahi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice
decreased CD4-positive, alpha-beta T cell number ( J:141144 )
• absolute numbers of CD4+ single positive mature thymocytes are reduced by 5 to 10 fold compared to controls
• the percentage of CD4+ T cells in peripheral lymph nodes is reduced by almost 20-fold

immune system
abnormal T cell differentiation ( J:141144 )
• the number of HSAhiCD69+ and HSAhi TCRbetahi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice
decreased CD4-positive, alpha-beta T cell number ( J:141144 )
• absolute numbers of CD4+ single positive mature thymocytes are reduced by 5 to 10 fold compared to controls
• the percentage of CD4+ T cells in peripheral lymph nodes is reduced by almost 20-fold




Genotype
MGI:3821708
cn4
Allelic
Composition		 Cbfbtm1Itan/Cbfbtm1Itan
Zbtb7btm2Litt/Zbtb7b+
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfbtm1Itan mutation (1 available); any Cbfb mutation (36 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Zbtb7btm2Litt mutation (2 available); any Zbtb7b mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal T cell differentiation ( J:141144 )
• the number of HSAhiCD69+ and HSAhi TCRbetahi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice
decreased CD4-positive, alpha-beta T cell number ( J:141144 )
• absolute numbers of CD4+ single positive mature thymocytes are reduced by 5 to 10 fold compared to controls
• however, the percentage of CD4+ T cells in peripheral lymph nodes is only slightly reduced

hematopoietic system
abnormal T cell differentiation ( J:141144 )
• the number of HSAhiCD69+ and HSAhi TCRbetahi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice
decreased CD4-positive, alpha-beta T cell number ( J:141144 )
• absolute numbers of CD4+ single positive mature thymocytes are reduced by 5 to 10 fold compared to controls
• however, the percentage of CD4+ T cells in peripheral lymph nodes is only slightly reduced




Genotype
MGI:3821709
cn5
Allelic
Composition		 Cbfbtm1Itan/Cbfbtm1Itan
Zbtb7btm2Litt/Zbtb7btm1.2Litt
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cbfbtm1Itan mutation (1 available); any Cbfb mutation (36 available)
Tg(Lck-cre)1Cwi mutation (3 available)
Zbtb7btm1.2Litt mutation (1 available); any Zbtb7b mutation (24 available)
Zbtb7btm2Litt mutation (2 available); any Zbtb7b mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell differentiation ( J:141144 )
• the number of HSAhiCD69+ and HSAhi TCRbetahi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice
decreased CD4-positive, alpha-beta T cell number ( J:141144 )
• absolute numbers of CD4+ single positive mature thymocytes are reduced between 5-10 fold compared to controls
• however, the percentage of CD4+ T cells in peripheral lymph nodes is only slightly reduced

immune system
abnormal T cell differentiation ( J:141144 )
• the number of HSAhiCD69+ and HSAhi TCRbetahi positively selected thymocytes are approximately 20% of those in littermate control or Zbtb7b-deficient mice
decreased CD4-positive, alpha-beta T cell number ( J:141144 )
• however, the percentage of CD4+ T cells in peripheral lymph nodes is only slightly reduced
• absolute numbers of CD4+ single positive mature thymocytes are reduced between 5-10 fold compared to controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory