Analysis Tools
mortality/aging
| N |
• mice are viable and fertile
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• in mice infected with Citrobacter rodentium
|
reproductive system
| N |
• mice are viable and fertile
|
immune system
| N |
• Background Sensitivity: mice on a congenic C57BL/6 background exhibit normal proportions of IFN-gamma and IL17A-producing CD4+ T cells in the large intestine lamina propria unlike mice on a mixed background
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• mice infected with Citrobacter rodentium exhibit severe weight loss, increased inflammation, increased tissue damage, increased cytokine expression, decreased regulatory T cell numbers in the large intestine lamina propria and death compared with control mice
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• in the large intestine lamina propria
• however, the numbers are normal in the small intestine
|
|
• small reduction in the large intestine lamina propria
• however, numbers are normal in the small intestine propria and spleen
|
|
• in the large intestine lamina propria
• however, the numbers are normal in the small intestine
|
|
• reduced percentage and cell number in the large intestine lamina propria
• in mice infected with Citrobacter rodentium
• however, percentages are normal in the small intestine propria and spleen
|
|
• regulatory T cells transferred into Rag2 null mice fail to reduce induced colitis unlike wild-type cells
• however, regulatory T cell exhibit normal ability to suppress naive T cell proliferation
|
|
• mice infected with Citrobacter rodentium exhibit severe weight loss, increased inflammation, increased tissue damage, increased cytokine expression, decreased regulatory T cell numbers in the large intestine lamina propria and death compared with control mice
• however, pathogen load in the large intestine and spleen is normal
|
|
• in mice infected with Citrobacter rodentium
|
digestive/alimentary system
|
• mice infected with Citrobacter rodentium exhibit severe weight loss, increased inflammation, increased tissue damage, increased cytokine expression, decreased regulatory T cell numbers in the large intestine lamina propria and death compared with control mice
|
growth/size/body
|
• severe in mice infected with Citrobacter rodentium
|
hematopoietic system
|
• in the large intestine lamina propria
• however, the numbers are normal in the small intestine
|
|
• small reduction in the large intestine lamina propria
• however, numbers are normal in the small intestine propria and spleen
|
|
• in the large intestine lamina propria
• however, the numbers are normal in the small intestine
|
|
• reduced percentage and cell number in the large intestine lamina propria
• in mice infected with Citrobacter rodentium
• however, percentages are normal in the small intestine propria and spleen
|
|
• regulatory T cells transferred into Rag2 null mice fail to reduce induced colitis unlike wild-type cells
• however, regulatory T cell exhibit normal ability to suppress naive T cell proliferation
|
|
• bone marrow transplanted into irradiated Foxp3sf mice confers increased susceptibility to Citrobacter rodentium-induced colitis
|
