Analysis Tools
nervous system
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• onset and duration of kainate -induced seizure activity is altered in these mice
• onset of seizures occurs significantly faster with mutant mice having high seizure scores within twenty minutes of injection compared to the moderate scores of wild-type mice
• mutant mice recover from induced seizures within 2 hours of induction compared to 4 hours for wild-type mice
• two of nine mutant mice died within 30 minutes of kainate injection compared to none of the wild-type mice
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• mice are protected from extensive pyramidal cell loss in the hippocampal CA3 region resulting from kainate injection
• the mice are also protected from neuroinflammation induced by kainate
• the neuronal damage score of this brain region is half that of wild-type mice injected with the same amount of kainate
• no injury is detectable in the CA1 region and in the granule cell layer of the dentate gyrus while in wild-type mice injury is sometimes observed
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behavior/neurological
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• onset and duration of kainate -induced seizure activity is altered in these mice
• onset of seizures occurs significantly faster with mutant mice having high seizure scores within twenty minutes of injection compared to the moderate scores of wild-type mice
• mutant mice recover from induced seizures within 2 hours of induction compared to 4 hours for wild-type mice
• two of nine mutant mice died within 30 minutes of kainate injection compared to none of the wild-type mice
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homeostasis/metabolism
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• mice are protected from extensive pyramidal cell loss in the hippocampal CA3 region resulting from kainate injection
• the mice are also protected from neuroinflammation induced by kainate
• the neuronal damage score of this brain region is half that of wild-type mice injected with the same amount of kainate
• no injury is detectable in the CA1 region and in the granule cell layer of the dentate gyrus while in wild-type mice injury is sometimes observed
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cellular
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• mice are protected from extensive pyramidal cell loss in the hippocampal CA3 region resulting from kainate injection
• the mice are also protected from neuroinflammation induced by kainate
• the neuronal damage score of this brain region is half that of wild-type mice injected with the same amount of kainate
• no injury is detectable in the CA1 region and in the granule cell layer of the dentate gyrus while in wild-type mice injury is sometimes observed
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