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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(tetO-Kdr*)4377.5Rwng
transgene insertion 4377.5, Rong Wang
MGI:3810550
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Kdrtm1Jrt/Kdr+
Tg(tetO-Kdr*)4377.5Rwng/0
Tg(Cebpb-tTA)5Bjd/0
involves: 129S1/Sv * 129X1/SvJ * FVB/N * NMRI MGI:3810713
cx2
Tg(tetO-Kdr*)4377.5Rwng/0
Tg(Cebpb-tTA)5Bjd/0
involves: FVB/N * NMRI MGI:3810712


Genotype
MGI:3810713
cx1
Allelic
Composition
Kdrtm1Jrt/Kdr+
Tg(tetO-Kdr*)4377.5Rwng/0
Tg(Cebpb-tTA)5Bjd/0
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1Jrt mutation (1 available); any Kdr mutation (48 available)
Tg(Cebpb-tTA)5Bjd mutation (3 available)
Tg(tetO-Kdr*)4377.5Rwng mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
liver/biliary system
• at E12.5, liver vasculature is less organized and vessels are dilated
• at E13.5, microvascular network is more disorganized with fewer branches than in control livers; newborns have very little microvascular network is observed




Genotype
MGI:3810712
cx2
Allelic
Composition
Tg(tetO-Kdr*)4377.5Rwng/0
Tg(Cebpb-tTA)5Bjd/0
Genetic
Background
involves: FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cebpb-tTA)5Bjd mutation (3 available)
Tg(tetO-Kdr*)4377.5Rwng mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• between 25% and 38% of pups are stillborn

liver/biliary system
N
• liver glycogen and albumin levels are comparable to control animals
• livers from neonates display a decrease in blood vessels
• livers of all newborn animals are dark red in appearance in contrast to pink color of control livers
• fewer endothelial cells (ECs) are present in mutant liver vasculature; ECs are present but are less organized and more discontinuous than in controls
• fewer or collapsed-appearing sinusoidal channels are observed
• livers have a sparse and poorly developed sinusoidal network with numerous blood cells in the disrupted sinusoidal spaces
• parenchymal cells contain very few or no lipid droplets
• morphology of space of Disse is abnormal, showing large gaps between sinusoidal epithelial cells (SECs) and hepatocytes
• sinusoidal epithelium lacks fenestrations seen in normal livers
• hepatocytes are more scattered than in control livers and many are oddly shaped with fewer microvilli projections into the space of Disse
• there is increase in red blood cells in liver due to defective circulation
• livers show a significant defect in lipoprotein uptake compared to controls
• 30 to 63% of newborns are jaundiced; suppression of transgenic Kdr by doxycycline treatement of dams during embryogenesis eliminates jaundice that is observed in untreated animals

cardiovascular system
• decreased number of blood vessels in liver

homeostasis/metabolism
N
• serum bilirubin levels are normal





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/12/2022
MGI 6.17
The Jackson Laboratory