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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Tg(tetO-MET)23Rwng
transgene insertion 23, Rong Wang
MGI:3810467
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cx1
Tg(tetO-MET)23Rwng/0
Tg(Cebpb-tTA)5Bjd/0
involves: FVB/N * NMRI MGI:3810811


Genotype
MGI:3810811
cx1
Allelic
Composition
Tg(tetO-MET)23Rwng/0
Tg(Cebpb-tTA)5Bjd/0
Genetic
Background
involves: FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cebpb-tTA)5Bjd mutation (3 available)
Tg(tetO-MET)23Rwng mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• mice from 2 lines (1 and 2) of double transgenic founders die within 2 months postpartum; early mortality can be prevented by repression of MET expression with doxycycline administration to mating parents, and then to pups until 4 weeks of age (J:69731)
• with this doxycycline treatment, animals appear normal until 10 months of age, then mice start dying (J:69731)
• mice from 2 other lines (3 and 4) of double transgenic parents are healthy at birth, then begin to die at 4 months of age (J:69731)
• mice from 2 lines (1 and 2) of double transgenic founders die within 2 months postpartum; early mortality can be prevented by repression of MET expression with doxycycline administration to mating parents, and then to pups until 4 weeks of age (J:69731)
• with this doxycycline treatment, animals appear normal until 10 months of age, then mice start dying (J:69731)
• mice from 2 other lines (3 and 4) of double transgenic parents are healthy at birth, then begin to die at 4 months of age (J:69731)

growth/size/body
• animals dying without evidence of tumors are usually cachexic (J:69731)
• animals dying without evidence of tumors are usually cachexic (J:69731)

liver/biliary system
• hepatocytes in foci of hyperplasia develop foamy cytoplasm containing fat deposits (J:69731)
• with progression of hyperplastic foci toward malignancy, cytologic changes are observed such as cellular and nuclear enlargement with disorganization of cell plate and lobular structures; malignant foci enlarge and develop trabeculae lined with endothelial cells, often separated from each other by blood-filled spaces (J:69731)
• hepatocytes in foci of hyperplasia develop foamy cytoplasm containing fat deposits (J:69731)
• with progression of hyperplastic foci toward malignancy, cytologic changes are observed such as cellular and nuclear enlargement with disorganization of cell plate and lobular structures; malignant foci enlarge and develop trabeculae lined with endothelial cells, often separated from each other by blood-filled spaces (J:69731)
• pups are born with enlarged and fatty livers (J:69731)
• pups are born with enlarged and fatty livers (J:69731)
• fully developed tumors often display areas of necrosis (J:69731)
• fully developed tumors often display areas of necrosis (J:69731)
• pups are born with enlarged and fatty livers (J:69731)
• pups are born with enlarged and fatty livers (J:69731)
• animals dying without evidence of tumors display jaundice (J:69731)
• animals dying without evidence of tumors display jaundice (J:69731)

tumorigenesis
• 85% of animals dying after 10 months after receiving DOX till 4 weeks of age show hepatocellular carcinoma (HCC); incidence by 1 year is >60% in lines 1 and 2 (J:69731)
• for lines 3 and 4, 85% of deaths are accompanied by HCC, which appears as an abdominal mass at 6 months of age or later; incidence by 1 year is 60% (J:69731)
• by 60 weeks of age, many small foci of hyperplasia are detected, often around central hepatic lobule and become more numerous, larger, and uniformly distributed by 4 months of age (J:69731)
• zones of progression to malignancy are observed within hyperplasias by 6 months, with cells in the zones showing poor organization and less differentiation than normal livers (J:69731)
• majority of moribund mice treated with doxycycline regain health tumors nearly regress completely, with liver morphology becoming almost normal by 4 months of treatment (J:69731)
• fully developed tumors often display areas of necrosis (J:69731)
• 85% of animals dying after 10 months after receiving DOX till 4 weeks of age show hepatocellular carcinoma (HCC); incidence by 1 year is >60% in lines 1 and 2 (J:69731)
• for lines 3 and 4, 85% of deaths are accompanied by HCC, which appears as an abdominal mass at 6 months of age or later; incidence by 1 year is 60% (J:69731)
• by 60 weeks of age, many small foci of hyperplasia are detected, often around central hepatic lobule and become more numerous, larger, and uniformly distributed by 4 months of age (J:69731)
• zones of progression to malignancy are observed within hyperplasias by 6 months, with cells in the zones showing poor organization and less differentiation than normal livers (J:69731)
• majority of moribund mice treated with doxycycline regain health tumors nearly regress completely, with liver morphology becoming almost normal by 4 months of treatment (J:69731)
• fully developed tumors often display areas of necrosis (J:69731)

Mouse Models of Human Disease
OMIM ID Ref(s)
Hepatocellular Carcinoma 114550 J:69731





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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory