Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp2tm1Ktas mutation
(0 available);
any
Sfrp2 mutation
(26 available)
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limbs/digits/tail
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• Background Sensitivity: penetrance is higher (about 96%) compared to homozygotes on a mixed 129X1/SvJ and C57BL/6 background
• hindlimbs are more severely affected than forelimbs but webbing is symmetrical between the left and right side
• penetration rate of webbing is highest for the interdigital spaces 2 and 3
• however, unlike mice on a mixed 129X1/SvJ and C57BL/6 background synpolydactyly is not seen
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• at E13.5 maturation of the digital analgen is disrupted and fused digital rays of presumptive phalanges are seen
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• at E14 programmed cell death in the proximal portion of the interdigit zone is severely diminished and shallow grooves appear in the distal but not the proximal portion of the interdigital zone
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• tail kinks result from perturbed growth of the vertebral bones
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• variable penetrance and variable severity
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skeleton
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• tail kinks result from perturbed growth of the vertebral bones
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• in caudal vertebrae growth plates chondrocyte differentiation is impaired
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cellular
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• at E14 programmed cell death in the proximal portion of the interdigit zone is severely diminished and shallow grooves appear in the distal but not the proximal portion of the interdigital zone
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|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp2tm1Ktas mutation
(0 available);
any
Sfrp2 mutation
(26 available)
|
|
|
limbs/digits/tail
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• hindlimbs are more severely affected than forelimbs and the webbing phenotype displays right side dominance
• interdigital space 1 is most severely affected and is accompanied by preaxial synpolydactyly
• Background Sensitivity: penetrance is lower (about 12%) compared to homozygotes on a 129X1/SvJ or mixed 129X1/SvJ and CBA/N background
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• Background Sensitivity: preaxial synpolydactyly is seen in 15% of mice on this background but not in mice on either a 129X1/SvJ or mixed 129X1/SvJ and CBA/N background
• preaxial synpolydactyly is often unilateral with a right side dominance and accompanied by syndactyly
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• at E13.5 maturation of the digital analgen is disrupted and fused digital rays of presumptive phalanges are seen
|
|
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• at E14 programmed cell death in the proximal portion of the interdigit zone is severely diminished and shallow grooves appear in the distal but not the proximal portion of the interdigital zone
|
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• tail kinks result from perturbed growth of the vertebral bones
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• variable penetrance and variable severity
|
skeleton
|
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• tail kinks result from perturbed growth of the vertebral bones
|
|
|
• in caudal vertebrae growth plates chondrocyte differentiation is impaired
|
cellular
|
|
• at E14 programmed cell death in the proximal portion of the interdigit zone is severely diminished and shallow grooves appear in the distal but not the proximal portion of the interdigital zone
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp2tm1Ktas mutation
(0 available);
any
Sfrp2 mutation
(26 available)
|
|
|
limbs/digits/tail
|
|
• hindlimbs are more severely affected than forelimbs but webbing is symmetrical between the left and right side
• penetration rate of webbing is highest for the interdigital spaces 2 and 3
• Background Sensitivity: penetrance is higher (about 95%) compared to homozygotes on a mixed 129X1/SvJ and C57BL/6 background
• however, unlike mice on a mixed 129X1/SvJ and C57BL/6 background synpolydactyly is not seen
|
|
|
• at E13.5 maturation of the digital analgen is disrupted and fused digital rays of presumptive phalanges are seen
|
|
|
• at E14 programmed cell death in the proximal portion of the interdigit zone is severely diminished and shallow grooves appear in the distal but not the proximal portion of the interdigital zone
|
|
|
• tail kinks result from perturbed growth of the vertebral bones
|
|
|
• variable penetrance and variable severity
|
skeleton
|
|
• tail kinks result from perturbed growth of the vertebral bones
|
|
|
• in caudal vertebrae growth plates chondrocyte differentiation is impaired
|
cellular
|
|
• at E14 programmed cell death in the proximal portion of the interdigit zone is severely diminished and shallow grooves appear in the distal but not the proximal portion of the interdigital zone
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Allelic
Composition |
Sfrp2tm1Ktas/Sfrp2+
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Genetic
Background |
involves: 129X1/SvJ |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp2tm1Ktas mutation
(0 available);
any
Sfrp2 mutation
(26 available)
|
|
|
limbs/digits/tail
|
|
• interdigital space 2 is less severely affected than interdigital space 3
• webbing is symmetrical between the left and right side
• Background Sensitivity: penetrance is higher (about 59%) compared to heterozygotes on a mixed 129X1/SvJ and C57BL/6 background
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Allelic
Composition |
Sfrp2tm1Ktas/Sfrp2+
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Genetic
Background |
involves: 129X1/SvJ * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp2tm1Ktas mutation
(0 available);
any
Sfrp2 mutation
(26 available)
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limbs/digits/tail
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N |
• Background Sensitivity: unlike mice on a 129X1/SvJ or mixed 129X1/SvJ and CBA/N background syndactyly is not seen
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Allelic
Composition |
Sfrp2tm1Ktas/Sfrp2+
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Genetic
Background |
involves: 129X1/SvJ * CBA/N |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sfrp2tm1Ktas mutation
(0 available);
any
Sfrp2 mutation
(26 available)
|
|
|
limbs/digits/tail
|
|
• interdigital space 2 is less severely affected than interdigital space 3
• webbing is symmetrical between the left and right side
• Background Sensitivity: penetrance is higher (about 24%) compared to heterozygotes on a mixed 129X1/SvJ and C57BL/6 background
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Analysis Tools