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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kif5btm1Njen
targeted mutation 1, Nancy A Jenkins
MGI:3809821
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Kif5btm1Njen/Kif5btm1Njen involves: 129S1/Sv MGI:4949222
cn2
 		Kif5btm1Njen/Kif5btm1.1Njen
Tg(Ins2-cre)25Mgn/0 		involves: 129S1/Sv * C57BL/6 * C57BL/6N * DBA * SJL MGI:4946372
cn3
 		Kif5btm1Njen/Kif5b+
Tg(Ins2-cre)25Mgn/0 		involves: 129S1/Sv * C57BL/6 * C57BL/6N * DBA * SJL MGI:4946373


Genotype
MGI:4949222
hm1
Allelic
Composition		 Kif5btm1Njen/Kif5btm1Njen
Genetic
Background		 involves: 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif5btm1Njen mutation (1 available); any Kif5b mutation (59 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal vesicle-mediated transport ( J:170887 )
• cre-treated neurons exhibit impaired retrograde vesicle transport compared with wild-type cells
• however, neurons exhibit normal anterograde




Genotype
MGI:4946372
cn2
Allelic
Composition		 Kif5btm1Njen/Kif5btm1.1Njen
Tg(Ins2-cre)25Mgn/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * C57BL/6N * DBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif5btm1.1Njen mutation (1 available); any Kif5b mutation (59 available)
Kif5btm1Njen mutation (1 available); any Kif5b mutation (59 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal pancreatic beta cell morphology ( J:170198 )
• mitochondria cluster in the perinuclear region unlike in wild-type beta cells
abnormal pancreas physiology ( J:170198 )
• islet cell proliferation is decreased compared to in control mice
• however, the rate of apoptosis is normal
abnormal pancreatic beta cell physiology ( J:170198 )
• mice exhibit an increase in insulin vesicles per cell area compared to in wild-type cells
decreased insulin secretion ( J:170198 )
• in early and slow phase after glucose injection
• after KCl-stimulation of islets
• however, insulin secretion is normal in the absence of glucose stimulation

homeostasis/metabolism
decreased insulin secretion ( J:170198 )
• in early and slow phase after glucose injection
• after KCl-stimulation of islets
• however, insulin secretion is normal in the absence of glucose stimulation
hyperglycemia ( J:170198 )
• progressive increase in random and 16-hour fasting conditions
decreased circulating insulin level ( J:170198 )
• in fasting conditions, but not in a random fed state
impaired glucose tolerance ( J:170198 )
• mice exhibit impaired glucose intolerance compared with wild-type mice
• however, blood glucose drops to wild-type levels 15 minutes after insulin injection

growth/size/body
decreased body weight ( J:170198 )
postnatal growth retardation ( J:170198 )




Genotype
MGI:4946373
cn3
Allelic
Composition		 Kif5btm1Njen/Kif5b+
Tg(Ins2-cre)25Mgn/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * C57BL/6N * DBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif5btm1Njen mutation (1 available); any Kif5b mutation (59 available)
Tg(Ins2-cre)25Mgn mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased insulin secretion ( J:170198 )
• slight after glucose injection

endocrine/exocrine glands
decreased insulin secretion ( J:170198 )
• slight after glucose injection




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory