All Phenotypes Xiap<tm1Hs> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Xiap^tm1Hs
targeted mutation Hermann Steller
MGI:3809790

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Xiap^tm1Hs/Xiap^tm1Hs	B6.129P2-Xiap^tm1Hs	MGI:3809793
cn2	Tg(IghMyc)22Bri/0 Xiap^tm1Hs/Xiap^tm1Hs	B6.Cg-Xiap^tm1Hs Tg(IghMyc)22Bri	MGI:3809794

Allelic Composition	Xiap^tm1Hs/Xiap^tm1Hs
Genetic Background	B6.129P2-Xiap^tm1Hs

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Xiap^tm1Hs mutation (1 available); any Xiap mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:138979 )

N	• mice are fertile

cellular

increased sensitivity to induced cell death ( J:138979 )

• mouse embryonic fibroblasts are more sensitive to TNF-alpha induced apoptosis compared to wild-type cells

immune system

immune system phenotype ( J:138979 )

N	• mice exhibit normal thymocyte apoptosis

Allelic Composition	Tg(IghMyc)22Bri/0 Xiap^tm1Hs/Xiap^tm1Hs
Genetic Background	B6.Cg-Xiap^tm1Hs Tg(IghMyc)22Bri

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(IghMyc)22Bri mutation (1 available)
Xiap^tm1Hs mutation (1 available); any Xiap mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:138979 )

N	• mice exhibit increased survival compared to Tg(IghMyc)22Bri mice

immune system

increased B cell apoptosis ( J:138979 )