Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation
(3 available);
any
Commd10 mutation
(24 available)
Ikzf1tm1.1(Pax5)Mbu mutation
(0 available);
any
Ikzf1 mutation
(30 available)
Tcf3tm1Mbu mutation
(1 available);
any
Tcf3 mutation
(39 available)
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immune system
N |
• development of pro-B cells is rescued
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• proximal VH7183-DJH and distal VHJ558-DJH rearrangements of the IgH are reduced compared to in wild-type mice
• Vk-Jk recombination of the Igk locus is absent
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hematopoietic system
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• proximal VH7183-DJH and distal VHJ558-DJH rearrangements of the IgH are reduced compared to in wild-type mice
• Vk-Jk recombination of the Igk locus is absent
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hematopoietic system
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• mice lack committed c-Kit+CD19+ pro-B cells
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immune system
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• mice lack committed c-Kit+CD19+ pro-B cells
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hematopoietic system
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• GFP+ pre-B cells are absent in the bone marrow
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immune system
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• GFP+ pre-B cells are absent in the bone marrow
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1.2Mbu mutation
(0 available);
any
Tcf3 mutation
(39 available)
Tcf3tm1Mbu mutation
(1 available);
any
Tcf3 mutation
(39 available)
Tg(Aicda-cre)9Mbu mutation
(2 available)
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immune system
N |
• despite reduced B cell numbers, class switching and B cell proliferation following stimulation are normal following immunization
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• following immunization, the number of IgG2a- and IgG3-secreting cells is decreased compared to in wild-type mice
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• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal
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• at day 4 following immunization, the number of germinal cell B cells in the spleen is reduced and remains 7- to 4-fold lower at day 8 and 12 compared to in wild-type and heterozygous mice
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hematopoietic system
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• following immunization, the number of IgG2a- and IgG3-secreting cells is decreased compared to in wild-type mice
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• at day 4 following immunization, the number of germinal cell B cells in the spleen is reduced and remains 7- to 4-fold lower at day 8 and 12 compared to in wild-type and heterozygous mice
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• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal
|
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1.2Mbu mutation
(0 available);
any
Tcf3 mutation
(39 available)
Tcf3tm1Mbu mutation
(1 available);
any
Tcf3 mutation
(39 available)
Tg(Fcer2a-cre)5Mbu mutation
(4 available)
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immune system
N |
• despite reduced B cell numbers, class switching, NP-specific production of IgG1, IgG2a and IgG3, B cell proliferation, memory B cells and plasma B cells following stimulation are normal following immunization
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• splenic B cell numbers are minimally reduced compared to in wild-type mice
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• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal
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• at 4 and 8 days after immunization germinal center B cell numbers are 3- to 5-fold lower tan in wild-type or heterozygous mice
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hematopoietic system
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• splenic B cell numbers are minimally reduced compared to in wild-type mice
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• at 4 and 8 days after immunization germinal center B cell numbers are 3- to 5-fold lower tan in wild-type or heterozygous mice
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• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal
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immune system
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• in the bone marrow, pro-B and re-circulating B cell numbers are decreased by half compared to in wild-type mice
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• in the bone marrow, total B cell number in the bone marrow is reduced to 30% of wild-type
• the spleen contains half the number of B cells as in wild-type mice
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• in the bone marrow, immature B cells are decreased to 18% of wild-type numbers
• in the spleen, immature B cells are reduced by 50% compared to in wild-type mice
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• in the spleen, transitional B cells are reduced by 50% compared to in wild-type mice
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• in the spleen, mature B cells are reduced by 50% compared to in wild-type mice
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• in the bone marrow, pre-B cells are decreased to 18% of wild-type numbers
• GFP+ pre-B cells are absent in the bone marrow
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hematopoietic system
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• in the bone marrow, pro-B and re-circulating B cell numbers are decreased by half compared to in wild-type mice
|
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• in the bone marrow, total B cell number in the bone marrow is reduced to 30% of wild-type
• the spleen contains half the number of B cells as in wild-type mice
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• in the bone marrow, immature B cells are decreased to 18% of wild-type numbers
• in the spleen, immature B cells are reduced by 50% compared to in wild-type mice
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• in the spleen, transitional B cells are reduced by 50% compared to in wild-type mice
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• in the spleen, mature B cells are reduced by 50% compared to in wild-type mice
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• in the bone marrow, pre-B cells are decreased to 18% of wild-type numbers
• GFP+ pre-B cells are absent in the bone marrow
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation
(3 available);
any
Commd10 mutation
(24 available)
Tcf3tm1Mbu mutation
(1 available);
any
Tcf3 mutation
(39 available)
Tg(Ikzf1-Tcfe2a,-GFP)1Mbu mutation
(0 available)
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immune system
N |
• c-Kit+B220+ pro-B cells and c-Kit-B220+ developmental stages are rescued
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