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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Hrastm2Xbr
targeted mutation 2, Xose R Bustelo
MGI:3803587
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Hrastm2Xbr/Hrastm2Xbr involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N MGI:3805200


Genotype
MGI:3805200
hm1
Allelic
Composition
Hrastm2Xbr/Hrastm2Xbr
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hrastm2Xbr mutation (1 available); any Hras mutation (30 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Virgin Hrastm2Xbr/Hrastm2Xbr females display mammary gland hyperplasia

muscle
• increased cardiomyocyte size
• elevated interstitial collagen deposition
• overall increase in size of walls and chamber
• cell size and density normal

neoplasm
N
• most (19/20) mice are tumor free at 18 months of age whereas about 10% pf humans with a comparable mutation develop various tumors
• one mouse in 20 has a mammary adenocarcinoma at 18 months
• epithelial in origin

endocrine/exocrine glands
• increased alveolar proliferation
• slight decrease in adipose tissue
• ductal ectasia
• mild periductal-alveolar fibrosis
• increased ductal branching
• greater ductal-lobulillar development
• one mouse in 20 has a mammary adenocarcinoma at 18 months
• epithelial in origin
• in females at around 4 months of age

craniofacial
• depression of anterior frontal bones
• shortened maxilla
• shortened molar process
• facial dysmorphia
• defects observed neonatally
• engrossed lips due to accumulation of adipocytes between skeletal muscle fascicules
• more sebaceous glands
• shorter elastin fibers
• narrowed choanae
• shortened and depressed nasal bridge
• shortened and depressed nasal bridge

cardiovascular system
N
• heart rate normal
• blood vessels generally more reactive to angiotensin II
• develop severe thickening and remodeling of aorta media over time
• changes less pronounced at 6 months than at 4 months
• sarcomere organization normal
• enlarged heart chambers at 4 months
• overall increase in size of walls and chambers
• cell size and density normal
• enlarged
• other heart valves normal
• enlarged heart chambers at 4 months
• increased cardiomyocyte size
• elevated interstitial collagen deposition
• overall increase in size of walls and chamber
• cell size and density normal
• systemic hypertension
• at least partially due to elevated circulating levels of angiotensin II
• pulmonary blood pressure is normal

renal/urinary system
N
• urine production normal
• sodium, potassium, chlorine excretion all normal

homeostasis/metabolism
• elevated circulating levels of angiotensin II

respiratory system
N
• breathing normal
• narrowed choanae
• shortened and depressed nasal bridge
• shortened and depressed nasal bridge

skeleton
• depression of anterior frontal bones
• shortened maxilla
• shortened molar process

integument
• increased alveolar proliferation
• slight decrease in adipose tissue
• ductal ectasia
• mild periductal-alveolar fibrosis
• increased ductal branching
• greater ductal-lobulillar development
• one mouse in 20 has a mammary adenocarcinoma at 18 months
• epithelial in origin
• in females at around 4 months of age
• distention and rounding of vibrissal follicles

growth/size/body
• increased cardiomyocyte size
• elevated interstitial collagen deposition
• overall increase in size of walls and chamber
• cell size and density normal
• facial dysmorphia
• defects observed neonatally
• engrossed lips due to accumulation of adipocytes between skeletal muscle fascicules
• more sebaceous glands
• shorter elastin fibers
• narrowed choanae
• shortened and depressed nasal bridge
• shortened and depressed nasal bridge

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Costello syndrome DOID:0050469 OMIM:218040
J:137729





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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory