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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Adgrg1tm1Lex
targeted mutation 1, Lexicon Genetics
MGI:3796624
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Adgrg1tm1Lex/Adgrg1tm1Lex involves: 129 * BALB/c * C57BL/6 * FVB/N MGI:3807039
ht2
Adgrg1tm1Lex/Adgrg1+ B6.129S5-Adgrg1tm1Lex MGI:5573240


Genotype
MGI:3807039
hm1
Allelic
Composition
Adgrg1tm1Lex/Adgrg1tm1Lex
Genetic
Background
involves: 129 * BALB/c * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrg1tm1Lex mutation (2 available); any Adgrg1 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• when challenged to walk on a narrow beam, mice exhibit more foot-slips than controls and took twice as long to cross the beam, suggesting modest motor impairment
• mice do not exhibit overt ataxia or gait abnormalities during normal behavior

nervous system
• radial glial endfeet are mispositioned and fibers are disorganized extending beyond the pia mater into the neuronal ectopia in the areas where the basement membrane is disrupted
• mice exhibit over-migration of some neurons through the marginal zone due to defects in the pial basement membrane
• however, migration of most neurons is normal
• at E18.5, the basement membrane in the cerebellum exhibits focal ruptures, disrupting migration of granule cells
• at E12.8, Cajal-Retzuis cells are malpositioned beyond the pial surface at defective basement membrane sites
• in the pons, the defects primarily involved loss of neurons in the pontine grey nuclei
• ectopic neurons, from both deep and superficial layers, are observed in the frontoparietal cortex due to over-migration of neurons through the marginal zone
• lamination beneath ectopic neurons is disorganized
• at E13.5, the pial basement membrane exhibits discontinuity that becomes more prominent at E14.5 and E16.5
• however, assembly of the basement membrane is normal
• fusion of adjacent lobules, disruption of normal layering, and ectopic clusters of neurons, spanned the entire mediolateral axis of the rostral cerebellum, including the vermis as well as cerebellar hemispheres
• rostral part of the cerebellum, encompassing lobules IV, was malformed in all homozygotes

cellular
• radial glial endfeet are mispositioned and fibers are disorganized extending beyond the pia mater into the neuronal ectopia in the areas where the basement membrane is disrupted
• mice exhibit over-migration of some neurons through the marginal zone due to defects in the pial basement membrane
• however, migration of most neurons is normal
• at E18.5, the basement membrane in the cerebellum exhibits focal ruptures, disrupting migration of granule cells
• at E18.5, the basement membrane in the cerebellum exhibits focal ruptures, disrupting migration of granule cells




Genotype
MGI:5573240
ht2
Allelic
Composition
Adgrg1tm1Lex/Adgrg1+
Genetic
Background
B6.129S5-Adgrg1tm1Lex
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adgrg1tm1Lex mutation (2 available); any Adgrg1 mutation (19 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular

endocrine/exocrine glands
• fragemented basement membrane in testis, mainly on the mesonephric side
• disrupted in some regions
• Sertoli cells were scattered in the defective areas of the testes, instead of forming tubular structures
• disrupted on the mesonephric side of the gonad

reproductive system
• fragemented basement membrane in testis, mainly on the mesonephric side
• disrupted in some regions
• Sertoli cells were scattered in the defective areas of the testes, instead of forming tubular structures
• disrupted on the mesonephric side of the gonad
• Background Sensitivity: on a C57BL/6J congenic background, reduced male fertility is seen compared to a mixed C57BL/6J and 129S5 background
• Background Sensitivity: progressive severity with age





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
03/24/2020
MGI 6.15
The Jackson Laboratory