Phenotypes associated with this allele

• Allele Symbol: Ackr3^tm1Jgo
• Allele Name: targeted mutation 1, Jan A Gossen
• Allele ID: MGI:3796065
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ackr3^tm1Jgo/Ackr3^tm1Jgo	involves: 129S/SvEvBrd * C57BL/6	MGI:4360728
ht2	Ackr3^tm1Jgo/Ackr3^+	involves: 129S/SvEvBrd * C57BL/6	MGI:4360726

Genotype
MGI:4360728

hm1

• Allelic Composition: Ackr3^tm1Jgo/Ackr3^tm1Jgo
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Enlarged hearts with cardiomyocyte hyperplasia, degeneration and fibrosis in some Ackr3^tm1Jgo/Ackr3^tm1Jgo mice

mortality/aging

decreased survivor rate ( J:136246 )

• 70% of mice born to heterozygote parents die in the first week of life while the remaining 30% have a normal lifespan

postnatal lethality, incomplete penetrance ( J:136246 )

• 70% of mice born to heterozygote parents die in the first week of life

• all mice born to homozygous parents die in the first week of life

cardiovascular system

myocardial fiber degeneration ( J:136246 )

• the majority of males and a third of females have fibrosis and myocardial degeneration

heart hyperplasia ( J:136246 )

• one-fourth of one day old pups have an enlarged heart

• about one-third of 18-week old mice have an enlarged heart due to cardiomyocyte hyperplasia

cardiac fibrosis ( J:136246 )

• the majority of males and a third of females have fibrosis and myocardial degeneration

immune system

lung inflammation ( J:136246 )

• peri-arteritis of the vasculature is found in a small subset of mice

• endothelial cells in these vessels are degenerated and areas of fibrosis surrounded these vessels

• alveolar macrophages had accumulated around these damaged vessels

homeostasis/metabolism

abnormal atrial thrombosis ( J:136246 )

• one quarter of adults have atrial thrombosis

muscle

myocardial fiber degeneration ( J:136246 )

• the majority of males and a third of females have fibrosis and myocardial degeneration

respiratory system

lung inflammation ( J:136246 )

• peri-arteritis of the vasculature is found in a small subset of mice

• endothelial cells in these vessels are degenerated and areas of fibrosis surrounded these vessels

• alveolar macrophages had accumulated around these damaged vessels

pulmonary fibrosis ( J:136246 )

• peri-arteritis of the vasculature is found in a small subset of mice

• endothelial cells in these vessels are degenerated and areas of fibrosis surrounded these vessels

growth/size/body

heart hyperplasia ( J:136246 )

• one-fourth of one day old pups have an enlarged heart

• about one-third of 18-week old mice have an enlarged heart due to cardiomyocyte hyperplasia

Genotype
MGI:4360726

ht2

• Allelic Composition: Ackr3^tm1Jgo/Ackr3⁺
• Genetic Background: involves: 129S/SvEvBrd * C57BL/6

cardiovascular system

myocardial fiber degeneration ( J:136246 )

• a third of females have fibrosis and myocardial degeneration

cardiac fibrosis ( J:136246 )

• a third of females have cardiac fibrosis and myocardial degeneration

respiratory system

lung inflammation ( J:136246 )

• peri-arteritis of the vasculature is found in a small subset of mice

• endothelial cells in these vessels are degenerated and areas of fibrosis surrounded these vessels

• alveolar macrophages had accumulated around these damaged vessels

pulmonary fibrosis ( J:136246 )

• peri-arteritis of the vasculature is found in a small subset of mice

• endothelial cells in these vessels are degenerated and areas of fibrosis surrounded these vessels

muscle

myocardial fiber degeneration ( J:136246 )

• a third of females have fibrosis and myocardial degeneration

immune system

lung inflammation ( J:136246 )

• peri-arteritis of the vasculature is found in a small subset of mice

• endothelial cells in these vessels are degenerated and areas of fibrosis surrounded these vessels

• alveolar macrophages had accumulated around these damaged vessels